Measurement of gastric emptying using a C-13-octanoic acid breath test with Wagner-Nelson analysis and scintigraphy in type 2 diabetes.

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dc.contributor.authorTrahair, L.G.
dc.contributor.authorNauck, M.A.
dc.contributor.authorWu, T.
dc.contributor.authorStevens, J.E.
dc.contributor.authorButtfield, M.D.
dc.contributor.authorHatzinikolas, S.
dc.contributor.authorPham, H.
dc.contributor.authorMeier, J.J.
dc.contributor.authorRayner, C.K.
dc.contributor.authorHorowitz, M.L.
dc.contributor.authorJones, K.
dc.date.issued2022
dc.description.abstractBackground: Breath tests utilising 13C-labelled substrates have been applied widely for the assessment of gastric emptying. A limitation of conventional breath test modelling is that the results should be regarded as notional, rather than precise. Wagner- Nelson analysis is a pharmacokinetic model that can be utilised to generate a gastric emptying curve from the % ¹³CO₂ measured in breath samples. Aims: To compare Wagner-Nelson analysis with (i) scintigraphy and (ii) conventional breath test modelling to quantify gastric emptying in type 2 diabetes. Methods: Thirteen subjects with type 2 diabetes (age 68.1±1.5 years, body mass index 31.0±0.9kg/m², glycated haemoglobin (HbA1c) 6.3±0.2%) consumed a mashed potato meal comprising 65g powdered potato, 20g glucose, 250ml water, an egg yolk labelled with 100μL 13Coctanoic acid and 20MBq 99mTc-calcium phytate. Scintigraphic data were acquired and breath samples collected for 4 hours after the meal. Gastric emptying curves were derived based on each technique; the 50% emptying time and intragastric retention at 60min were also calculated. Results: With Wagner-Nelson analysis, a Kel=0.60 (the elimination constant) best approximated the scintigraphic gastric emptying curve. There was a relationship between the T50 calculated with scintigraphy and that by both Wagner-Nelson Kel=0.60 (r²=0.45, P<0.05) and conventional analysis (r²=0.44, P<0.05). There was no significant difference in the 50% gastric emptying time measured by scintigraphy (68.5±4.8 min) and Wagner-Nelson Kel=0.60 (71.3±4.5 min), however, the gastric emptying time calculated by conventional analysis was much greater at 164.7±6.0 min (P<0.001). Conclusion: In type 2 diabetes, gastric emptying of a mashed potato meal measured using a ¹³C-octanoic acid breath test analysed with Wagner-Nelson Kel=0.60 closely reflects measurements obtained with scintigraphy, whereas, in absolute terms, the conventional breath test analysis does not.
dc.description.statementofresponsibilityG. Trahair, M. A. Nauck, T. Wu, J. E. Stevens, M. D. Buttfield, S Hatzinikolas, H. Pham, J. J. Meier, C. K. Rayner, M. Horowitz, K. Jones
dc.identifier.citationInternal Medicine Journal, 2022; 52(S2):54-55
dc.identifier.doi10.1111/imj.15763
dc.identifier.issn1444-0903
dc.identifier.issn1445-5994
dc.identifier.orcidWu, T. [0000-0003-1656-9210]
dc.identifier.orcidPham, H. [0000-0002-7055-3108]
dc.identifier.orcidRayner, C.K. [0000-0002-5527-256X]
dc.identifier.orcidHorowitz, M.L. [0000-0002-0942-0306]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.urihttps://hdl.handle.net/2440/146218
dc.language.isoen
dc.publisherWiley
dc.rights© 2022 Royal Australasian College of Physicians. Copyright of individual abstracts remains with the authors.
dc.source.urihttps://doi.org/10.1111/imj.15763
dc.subjectGeneral & Internal Medicine; Life Sciences & Biomedicine; Medicine, General & Internal; Science & Technology
dc.titleMeasurement of gastric emptying using a C-13-octanoic acid breath test with Wagner-Nelson analysis and scintigraphy in type 2 diabetes.
dc.typeJournal article
pubs.publication-statusPublished

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