Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen
Date
2000
Authors
Craddock, C.
Bardy, P.
Kreiter, S.
Johnston, R.
Apperley, J.
Marks, D.
Huber, C.
Kolbe, K.
Goulding, R.
Lawler, M.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
British Journal of Haematology, 2000; 111(3):797-800
Statement of Responsibility
C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs
Conference Name
Abstract
Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.
School/Discipline
Dissertation Note
Provenance
Published Online: 2 Aug 2008
Description
The definitive version may be found at www.wiley.com