Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen

Date

2000

Authors

Craddock, C.
Bardy, P.
Kreiter, S.
Johnston, R.
Apperley, J.
Marks, D.
Huber, C.
Kolbe, K.
Goulding, R.
Lawler, M.

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Journal article

Citation

British Journal of Haematology, 2000; 111(3):797-800

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C. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs

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Abstract

Graft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.

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Published Online: 2 Aug 2008

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The definitive version may be found at www.wiley.com

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