Engraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen

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dc.contributor.authorCraddock, C.
dc.contributor.authorBardy, P.
dc.contributor.authorKreiter, S.
dc.contributor.authorJohnston, R.
dc.contributor.authorApperley, J.
dc.contributor.authorMarks, D.
dc.contributor.authorHuber, C.
dc.contributor.authorKolbe, K.
dc.contributor.authorGoulding, R.
dc.contributor.authorLawler, M.
dc.contributor.authorGoldman, J.
dc.contributor.authorHughes, T.
dc.contributor.authorDerigs, G.
dc.date.issued2000
dc.descriptionThe definitive version may be found at www.wiley.com
dc.description.abstractGraft-versus-host disease (GVHD) remains a significant complication in patients undergoing allogeneic stem cell transplantation (SCT) using a reduced intensity conditioning regimen. Although T-cell depletion (TCD) reduces the risk of GVHD after a myeloablative conditioning regimen, it is associated with an increased risk of graft failure. We have therefore examined whether TCD compromises engraftment using a fludarabine-based conditioning regimen. Fifteen patients have been transplanted using such a regimen of whom 13 underwent ex vivo TCD. All but one patient demonstrated durable engraftment and no patient receiving a TCD product developed severe GVHD. Thus, TCD may play a role in GvHD prophylaxis using such regimens.
dc.description.statementofresponsibilityC. Craddock, P. Bardy, S. Kreiter, R. Johnston, J. Apperley, D. Marks, C. Huber, K. Kolbe, R. Goulding, M. Lawler, J. Goldman, T. Hughes and G. Derigs
dc.identifier.citationBritish Journal of Haematology, 2000; 111(3):797-800
dc.identifier.doi10.1111/j.1365-2141.2000.02454.x
dc.identifier.issn0007-1048
dc.identifier.issn1365-2141
dc.identifier.orcidHughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509]
dc.identifier.urihttp://hdl.handle.net/2440/9330
dc.language.isoen
dc.provenancePublished Online: 2 Aug 2008
dc.publisherBlackwell Publishing Ltd
dc.source.urihttps://doi.org/10.1111/j.1365-2141.2000.02454.x
dc.subjectT-Lymphocytes
dc.subjectHumans
dc.subjectLeukemia
dc.subjectMultiple Myeloma
dc.subjectGraft vs Host Disease
dc.subjectLymphocyte Depletion
dc.subjectTransplantation Conditioning
dc.subjectHematopoietic Stem Cell Transplantation
dc.subjectTransplantation, Homologous
dc.subjectAdult
dc.subjectAged
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.titleEngraftment of T-cell-depleted allogeneic haematopoietic stem cells using a reduced intensity conditioning regimen
dc.typeJournal article
pubs.publication-statusPublished

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