A comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma

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dc.contributor.authorKao, S.S.
dc.contributor.authorMicklem, J.
dc.contributor.authorOfo, E.
dc.contributor.authorEdwards, S.
dc.contributor.authorDhatrak, D.
dc.contributor.authorForeman, A.
dc.contributor.authorKrishnan, S.
dc.contributor.authorHodge, J.C.
dc.date.issued2017
dc.description.abstractThe incidence of oropharyngeal squamous cell carcinoma in the Western world is increasing, with the human papillomavirus epidemic implicated in this observed trend. The optimal treatment modality is yet undetermined regarding oncological outcomes.This study comprised 98 patients with oropharyngeal squamous cell carcinoma, treated with either primary transoral surgery with adjuvant therapy or primary chemoradiotherapy with curative intent, between 2008 and 2012. Clinicopathological characteristics including tumour-node-metastasis stage, human papillomavirus status, treatment modality, recurrence and overall survival were collated.Five per cent of primary surgical patients had locoregional recurrences compared with 25 per cent of primary chemoradiotherapy patients. A lower rate of locoregional recurrence was observed in the human papillomavirus positive group.This paper reports higher rates of overall survival and local control for oropharyngeal squamous cell carcinoma treated with primary surgery compared with primary chemoradiotherapy. This reflects overall lower tumour stage and higher human papillomavirus status in this group.
dc.description.statementofresponsibilityS S Kao, J Micklem, E Ofo, S Edwards, D Dhatrak, A Foreman, S Krishnan, J-C Hodge
dc.identifier.citationJournal of Laryngology and Otology, 2017; 132(4):349-355
dc.identifier.doi10.1017/S0022215117000986
dc.identifier.issn0022-2151
dc.identifier.issn1748-5460
dc.identifier.orcidKao, S.S. [0000-0003-0207-433X]
dc.identifier.orcidEdwards, S. [0000-0003-2074-1685]
dc.identifier.orcidForeman, A. [0000-0002-6560-6391]
dc.identifier.urihttp://hdl.handle.net/2440/115105
dc.language.isoen
dc.publisherCambridge University Press
dc.rights© JLO (1984) Limited, 2017
dc.source.urihttps://doi.org/10.1017/s0022215117000986
dc.subjectOropharynx; squamous cell carcinoma; robotic surgical procedures; recurrence; human papilloma virus
dc.titleA comparison of oncological outcomes between transoral surgical and non-surgical treatment protocols in the management of oropharyngeal squamous cell carcinoma
dc.typeJournal article
pubs.publication-statusPublished

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