NRG1 gene in recurrent major depression: No association in a large-scale case-control association study

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dc.contributor.authorSchosser, A.
dc.contributor.authorCohen-Woods, S.
dc.contributor.authorGaysina, D.
dc.contributor.authorChow, P.
dc.contributor.authorMartucci, L.
dc.contributor.authorFarmer, A.
dc.contributor.authorKorszun, A.
dc.contributor.authorGunasinghe, C.
dc.contributor.authorGray, J.
dc.contributor.authorJones, L.
dc.contributor.authorCraddock, N.
dc.contributor.authorOwen, M.
dc.contributor.authorCraig, I.
dc.contributor.authorMcGuffin, P.
dc.date.issued2010
dc.description.abstractThe Neuregulin 1 (NRG1) gene was initially implicated in schizophrenia (SZ) and has recently been associated with bipolar disorder (BPD) in two studies. An association with major depressive disorder (MDD) has not yet been investigated but is warranted in view of the genetic overlap between MDD and BPD. We have performed a large-scale case-control study investigating the association between NRG1 polymorphisms and MDD, genotyping a selection of 14 single nucleotide polymorphisms (SNPs) spanning the NRG1 gene in a sample of 1,398 patients of White European ancestry with a diagnosis of MDD and 1,304 ethnically matched controls from three clinical sites in the UK. We found no single marker or haplotype associations that withstood correction for multiple testing. Our findings do not provide evidence that NRG1 plays a role in MDD or that this gene explains part of the genetic overlap with BPD.
dc.description.statementofresponsibilityA. Schosser, S. Cohen-Woods, D. Gaysina, P.C. Chow, L. Martucci, A. Farmer, A. Korszun, C. Gunashinghe, J. Gray, L. Jones, N. Craddock, M.J. Owen, I.W. Craig, and P. McGuffin
dc.identifier.citationAmerican Journal of Medical Genetics, Part B: Neuropsychiatric Genetics, 2010; 153B(1):141-147
dc.identifier.doi10.1002/ajmg.b.30965
dc.identifier.issn1552-4841
dc.identifier.issn1552-485X
dc.identifier.orcidCohen-Woods, S. [0000-0003-2199-6129]
dc.identifier.urihttp://hdl.handle.net/2440/76337
dc.language.isoen
dc.publisherWiley-Liss
dc.rightsCopyright © 2009 Wiley-Liss, Inc.
dc.source.urihttps://doi.org/10.1002/ajmg.b.30965
dc.subjectNRG1
dc.subjectdepression
dc.subjectassociation
dc.subjectaffective disorders
dc.titleNRG1 gene in recurrent major depression: No association in a large-scale case-control association study
dc.typeJournal article
pubs.publication-statusPublished

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