Efficacy of targeting the P13 kinase and mTOR pathways as a treatment modality for multiple myeloma /
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(Published version)
Date
2014
Authors
Gan, Zhen Ying,
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thesis
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Abstract
Multiple myeloma (MM) is an incurable haematological malignancy characterised by the uncontrolled proliferation of clonal plasma cells within the bone marrow (BM).MM patients present with osteolytic bone lesions throughout the axial and apendicular skeleton, pathological fractures, spinal cord compression, hypercalcaemia, renal failure and immunosuppression. Approximately 10-15% of MM patients have been shown to have chromosomal trans locations involving the phosphatidylinositol 3-kinase (PI3k)and mammalian target of rapamycin (mTOR) pathways. The PI3k and mTOR pathways mediate cellular proliferation, growth and survival. In MM, these pathways promote uncontrolled plasma cell proliferation, cell survival and protection against apoptosis.The PI3k and mTOR pathways have also been shown to be important in osteoblast and osteoclast formation and function.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (Master of Science(Pharmacy))--University of South Australia, 2014.
Provenance
Copyright 2014 Zhen Ying Gan. This work is made available under the Creative Commons Attribution-NonCommercial- NoDerivs Australia 3.0 licence (http://creativecommons.org/licenses/by-nc-nd/3.0/au/)
Description
1 ethesis (321 pages) :
illustrations.
Includes bibliographical references.
illustrations.
Includes bibliographical references.
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506 0#$fstar $2Unrestricted online access