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Efficacy of targeting the P13 kinase and mTOR pathways as a treatment modality for multiple myeloma /

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dc.contributor.authorGan, Zhen Ying,
dc.contributor.schoolUniversity of South Australia. School of Pharmacy and Medical Sciences.
dc.contributor.schoolSchool of Pharmacy and Medical Sciences.
dc.date.issued2014
dc.description1 ethesis (321 pages) :
dc.descriptionillustrations.
dc.descriptionIncludes bibliographical references.
dc.description.abstractMultiple myeloma (MM) is an incurable haematological malignancy characterised by the uncontrolled proliferation of clonal plasma cells within the bone marrow (BM).MM patients present with osteolytic bone lesions throughout the axial and apendicular skeleton, pathological fractures, spinal cord compression, hypercalcaemia, renal failure and immunosuppression. Approximately 10-15% of MM patients have been shown to have chromosomal trans locations involving the phosphatidylinositol 3-kinase (PI3k)and mammalian target of rapamycin (mTOR) pathways. The PI3k and mTOR pathways mediate cellular proliferation, growth and survival. In MM, these pathways promote uncontrolled plasma cell proliferation, cell survival and protection against apoptosis.The PI3k and mTOR pathways have also been shown to be important in osteoblast and osteoclast formation and function.
dc.description.dissertationThesis (Master of Science(Pharmacy))--University of South Australia, 2014.
dc.identifier.urihttps://hdl.handle.net/11541.2/133325
dc.language.isoen
dc.provenanceCopyright 2014 Zhen Ying Gan. This work is made available under the Creative Commons Attribution-NonCommercial- NoDerivs Australia 3.0 licence (http://creativecommons.org/licenses/by-nc-nd/3.0/au/)
dc.subject.lcshBlood
dc.subject.lcshHematology.
dc.subject.lcshMultiple myeloma
dc.titleEfficacy of targeting the P13 kinase and mTOR pathways as a treatment modality for multiple myeloma /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12146685620001831 13146709650001831 9915935809801831_53114869540001831.pdf
ror.mmsid9915935809801831

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