Staining of amyloid precursor protein to study axonal damage in mild head injury
Date
1994
Authors
Blumbergs, P.
Scott, G.
Manavis, J.
Wainwright, H.
Simpson, D.
McLean, J.
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Advisors
Journal Title
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Type:
Journal article
Citation
The Lancet, 1994; 344(8929):1055-1056
Statement of Responsibility
P.C. Blumbergs, G. Scott, J. Manavis , H. Wainwright, D.A. Simpson & A.J. McLean
Conference Name
Abstract
The most common definition of cerebral concussion is that of a transient loss of neurological function without macroscopic or microscopic abnormality in the brain. However, some patients have persistent symptoms and subtle neuropsychological deficits, particularly affecting memory. We have studied five patients aged 59-89 years who sustained mild concussive head injury and died of other causes (2-99 days post-injury). Immunostaining with an antibody to amyloid precursor protein, a marker of fast axonal transport, showed multifocal axonal injury in all five. All had axonal damage in the fornices, which are important in memory function.
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(c) 1994 the Lancet