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Integrative assessment of brain and cognitive function in post-traumatic stress disorder

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dc.contributor.authorVeltmeyer, M.
dc.contributor.authorClark, C.
dc.contributor.authorMcFarlane, A.
dc.contributor.authorFelmingham, K.
dc.contributor.authorBryant, R.
dc.contributor.authorGordon, E.
dc.date.issued2005
dc.descriptionCopyright © 2005 Imperial College Press
dc.description.abstractThe present study combined neuropsychological and electrophysiological measures to obtain a comprehensive profile of the everyday attentional and memory dysfunction reported in PTSD. The event-related potential (ERP) literature has consistently found abnormalities in late components (N2, P3) reflecting working memory (WM) function. However, the neuropsychological profile reported in the literature has considerable variation. The present study examined ERP activity in 33 PTSD participants and matched controls during a standard two-tone auditory oddball task. Neuropsychological assessment was carried out using a task battery assessing a wide range of cognitive functions. Consistent with previous work, the PTSD group showed delayed N2 latency and reduced P3 target amplitude, together with slower and less accurate target detection. Scalp topography provided evidence of widespread abnormality during WM function, but with strongest effects broadly over the left hemisphere. Neuropsychological testing found concomitant difficulties on factorial measures of verbal memory retention/access and sustained attention but enhanced performance on measures of immediate recall. This integrative pattern of effects reflects a specific impairment in the operation of working memory systems that guide ongoing, planned behavior and that facilitate the acquisition and retention of new memories.
dc.description.statementofresponsibilityMelinda D. Veltmeyer; C. Richard Clark; Alexander C. McFarlane; Kim L. Felmingham; Richard A. Bryant; Evian Gordon
dc.identifier.citationJournal of Integrative Neuroscience, 2005; 4(1):145-159
dc.identifier.doi10.1142/S0219635205000719
dc.identifier.issn0219-6352
dc.identifier.issn1757-448X
dc.identifier.orcidMcFarlane, A. [0000-0002-3829-9509]
dc.identifier.urihttp://hdl.handle.net/2440/17438
dc.language.isoen
dc.publisherInperial College Press
dc.source.urihttps://doi.org/10.1142/s0219635205000719
dc.subjectBrain
dc.subjectHumans
dc.subjectElectroencephalography
dc.subjectVerbal Behavior
dc.subjectCognition
dc.subjectMaze Learning
dc.subjectMemory, Short-Term
dc.subjectChoice Behavior
dc.subjectPsychomotor Performance
dc.subjectArousal
dc.subjectAttention
dc.subjectReaction Time
dc.subjectStress Disorders, Post-Traumatic
dc.subjectPsychiatric Status Rating Scales
dc.subjectElectrophysiology
dc.subjectEvoked Potentials
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleIntegrative assessment of brain and cognitive function in post-traumatic stress disorder
dc.typeJournal article
pubs.publication-statusPublished

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