Symptomatic and preventive medication use according to age and frailty in Australian and Japanese nursing homes

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dc.contributor.authorLiau, S.J.
dc.contributor.authorHamada, S.
dc.contributor.authorJadczak, A.D.
dc.contributor.authorSakata, N.
dc.contributor.authorLalic, S.
dc.contributor.authorTsuchiya-Ito, R.
dc.contributor.authorTaguchi, R.
dc.contributor.authorVisvanathan, R.
dc.contributor.authorBell, J.S.
dc.date.issued2023
dc.description.abstractObjective To investigate symptomatic and preventive medication use according to age and frailty in Australian and Japanese nursing homes (NHs). Methods Secondary cross-sectional analyses of two prospective cohort studies involving 12 Australian NHs and four Japanese NHs. Frailty was measured using the FRAIL-NH scale (non-frail 0–2; frail 3–6; most-frail 7–14). Regular medications were classified as symptomatic or preventive based on published lists and expert consensus. Descriptive statistics were used to compare the prevalence and ratio of symptomatic to preventive medications. Results Overall, 550 Australian residents (87.7 ± 7.3 years; 73.3% females) and 333 Japanese residents (86.5 ± 7.0 years; 73.3% females) were included. Australian residents used a higher mean number of medications than Japanese residents (9.8 ± 4.0 vs 7.7 ± 3.7, p < 0.0001). Australian residents used more preventive than symptomatic medications (5.5 ± 2.5 vs 4.3 ± 2.6, p < 0.0001), while Japanese residents used more symptomatic than preventive medications (4.7 ± 2.6 vs 3.0 ± 2.2, p < 0.0001). In Australia, symptomatic medications were more prevalent with increasing frailty (non-frail 3.4 ± 2.6; frail 4.0 ± 2.6; most-frail 4.8 ± 2.6, p < 0.0001) but less prevalent with age (< 80 years 5.0 ± 2.9; 80–89 years 4.4 ± 2.6; ≥ 90 years 3.9 ± 2.5, p = 0.0042); while preventive medications remained similar across age and frailty groups. In Japan, there was no significant difference in the mean number of symptomatic and preventive medications irrespective of age and frailty. Conclusions The ratio of symptomatic to preventive medications was higher with increasing frailty but lower with age in Australia; whereas in Japan, the ratio remained consistent across age and frailty groups. Preventive medications remained prevalent in most-frail residents in both cohorts, albeit at lower levels in Japan.
dc.description.statementofresponsibilityShin J. Liau, Shota Hamada, Agathe D. Jadczak, Nobuo Sakata, Samanta Lalic, Rumiko Tsuchiya, Ito, Reina Taguchi, Renuka Visvanathan, J. Simon Bell
dc.identifier.citationAging clinical and experimental research, 2023; 34(12):3047-3057
dc.identifier.doi10.1007/s40520-023-02600-x
dc.identifier.issn1594-0667
dc.identifier.issn1720-8319
dc.identifier.orcidJadczak, A.D. [0000-0002-7501-7996]
dc.identifier.orcidVisvanathan, R. [0000-0002-1303-9479]
dc.identifier.urihttps://hdl.handle.net/2440/140897
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.grantNHMRC
dc.rights© The Author(s) 2023. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1007/s40520-023-02600-x
dc.subjectAged; Frailty; Nursing home; Polypharmacy; Medication review; Deprescribing
dc.subject.meshHumans
dc.subject.meshProspective Studies
dc.subject.meshCross-Sectional Studies
dc.subject.meshAged
dc.subject.meshAged, 80 and over
dc.subject.meshFrail Elderly
dc.subject.meshNursing Homes
dc.subject.meshJapan
dc.subject.meshAustralia
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshFrailty
dc.titleSymptomatic and preventive medication use according to age and frailty in Australian and Japanese nursing homes
dc.typeJournal article
pubs.publication-statusPublished online

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