Control strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration

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dc.contributor.authorGerstweiler, L.
dc.contributor.authorBillakanti, J.
dc.contributor.authorBi, J.
dc.contributor.authorMiddelberg, A.P.J.
dc.date.issued2022
dc.description.abstractFluctuations of the inlet feed stream concentration are a challenge in controlling continuous multicolumn counter current chromatography systems with standard methods. We propose a new control strategy based on calculated product column breakthrough from UV sensor signals by neglecting an impurity baseline and instead using the impurity to product ratio. This calculation is independent of the inlet feed concentration. In-silico simulation showed that the proposed method can calculate the product column breakthrough perfectly even with fluctuating and highly unstable inlet feed concentration during a loading cycle. Applying the proposed method to control a three column periodic counter current chromatography process with fluctuating inlet feed concentration resulted in constant column loading in each cycle, while using the standard method failed to do so. Unavoidable band broadening caused by diffusion and dispersion has been identified as an inherent limiting factor for accurate calculation of column breakthrough comparing inlet and outlet UV signals. The proposed advanced calculations increase the robustness of periodic counter current chromatography and extend the capability to process unstable inlet streams.
dc.description.statementofresponsibilityLukas Gerstweiler, Jagan Billakanti, Jingxiu Bi, Anton P.J. Middelberg
dc.identifier.citationJournal of Chromatography A, 2022; 1667:462884-1-462884-8
dc.identifier.doi10.1016/j.chroma.2022.462884
dc.identifier.issn0021-9673
dc.identifier.issn1873-3778
dc.identifier.orcidGerstweiler, L. [0000-0002-2421-5503]
dc.identifier.orcidBi, J. [0000-0001-7056-8572]
dc.identifier.urihttps://hdl.handle.net/2440/138654
dc.language.isoen
dc.publisherElsevier BV
dc.rights© 2022 Elsevier B.V. All rights reserved
dc.source.urihttps://doi.org/10.1016/j.chroma.2022.462884
dc.subjectPeriodic counter current chromatography; Continuous downstream processing; Controlling; Fluctuating concentration; Process integration
dc.subject.meshChromatography
dc.subject.meshDiffusion
dc.subject.meshComputer Simulation
dc.subject.meshBays
dc.titleControl strategy for multi-column continuous periodic counter current chromatography subject to fluctuating inlet stream concentration
dc.typeJournal article
pubs.publication-statusPublished

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