Accidental and Regulated Cell Death in Yeast Colony Biofilms

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dc.contributor.authorNetherwood, D.J.
dc.contributor.authorTam, A.K.Y.
dc.contributor.authorGourlay, C.W.
dc.contributor.authorKnežević, T.
dc.contributor.authorGardner, J.M.
dc.contributor.authorJiranek, V.
dc.contributor.authorBinder, B.J.
dc.contributor.authorGreen, J.E.F.
dc.date.issued2025
dc.description.abstractThe yeast species Saccharomyces cerevisiae is one of the most intensively studied organisms on the planet due to it being an excellent eukaryotic model organism in molecular and cell biology. In this work, we investigate the growth and morphology of yeast colony biofilms, where proliferating yeast cells reside within a self-produced extracellular matrix. This research area has garnered significant scientific interest due to its applicability in the biological and biomedical sectors. A central feature of yeast colony biofilm expansion is cellular demise, which is onset by one of two independent mechanisms: either accidental cell death (ACD) or regulated cell death (RCD). In this article, we generalise a continuum model for the nutrient-limited growth of a yeast colony biofilm to include the effects of ACD and RCD. This new model involves a system of four coupled nonlinear reaction-diffusion equations for the yeast-cell density, the nutrient concentration, and two species of dead cells. Numerical solutions of the spatially one and two-dimensional governing equations reveal the impact that ACD and RCD have on expansion speed, morphology and cell distribution within the colony biofilm. Our results are in good qualitative agreement with our own experiments.
dc.description.statementofresponsibilityDaniel J. Netherwood, Alexander K. Y. Tam, Campbell W. Gourlay, Tea Kneževic, Jennifer M. Gardner, Vladimir Jiranek, Benjamin J. Binder, J. Edward F. Green
dc.identifier.citationBulletin of Mathematical Biology, 2025; 87(8):110-1-110-23
dc.identifier.doi10.1007/s11538-025-01470-w
dc.identifier.issn0092-8240
dc.identifier.issn0092-8240
dc.identifier.orcidNetherwood, D.J. [0000-0002-3428-0165]
dc.identifier.orcidGardner, J.M. [0000-0002-4215-955X]
dc.identifier.orcidJiranek, V. [0000-0002-9775-8963]
dc.identifier.orcidBinder, B.J. [0000-0002-1812-6715]
dc.identifier.orcidGreen, J.E.F. [0000-0001-5061-9563]
dc.identifier.urihttps://hdl.handle.net/2440/146381
dc.language.isoen
dc.publisherSpringer
dc.relation.granthttp://purl.org/au-research/grants/arc/DP230100406
dc.relation.granthttp://purl.org/au-research/grants/arc/DE240100897
dc.rights© The Author(s) 2025. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
dc.source.urihttps://doi.org/10.1007/s11538-025-01470-w
dc.subjectApoptosis
dc.subjectInstability
dc.subjectNecrosis
dc.subjectPhloxine B
dc.subjectReaction–diffusion
dc.subjectSaccharomyces cerevisiae
dc.subject.meshBiofilms
dc.subject.meshSaccharomyces cerevisiae
dc.subject.meshModels, Biological
dc.subject.meshMathematical Concepts
dc.subject.meshCell Death
dc.subject.meshComputer Simulation
dc.subject.meshNonlinear Dynamics
dc.titleAccidental and Regulated Cell Death in Yeast Colony Biofilms
dc.typeJournal article
pubs.publication-statusPublished

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