Preparation of (–)-(7R)-7-acetyl-7-hydroxy-4,4-dimethoxy-5,6,7,8-tetrahydro-naphthalen-1(4H)-one, a chiral AB-synthon for anthracycline synthesis
Date
1981
Authors
Warrener, R.N.
Gee, P.S.
Russell, R.A.
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Journal article
Citation
Journal of the Chemical Society, Chemical Communications, 1981; 1981(21):1100-1101
Statement of Responsibility
Ronald N. Warrener, Paul S. Gee and Richard A. Russell
Conference Name
Abstract
The (–)-(R)-dienone (13) was prepared in 10 steps from the known 8-hydroxy-5-methoxy-2, 3-dihydronaphthalen-1(4H)-one (2), and the chirality at C(7) in (13) corresponds to that found at C(9) in the naturally occurring anthracyclines related to daunomycin.
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