The role of TGF-β in polycystic ovary syndrome

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dc.contributor.authorRaja-Khan, N.
dc.contributor.authorUrbanek, M.
dc.contributor.authorRodgers, R.
dc.contributor.authorLegro, R.
dc.date.issued2014
dc.description.abstractPolycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by chronic oligoanovulation and hyperandrogenism and associated with insulin resistance, type 2 diabetes, and cardiovascular risk. In recent years, genetic studies have linked PCOS to a dinucleotide marker D19S884 in the fibrillin 3 gene. Fibrillins make up the major component of microfibrils in the extracellular matrix (ECM) and interact with molecules in the ECM to regulate transforming growth factor β (TGF-β) signaling. Therefore, variations in fibrillin 3 and subsequent dysregulation of TGF-β may contribute to the pathogenesis of PCOS. Here, we review the evidence from genetic studies supporting the role of TGF-β in PCOS and describe how TGF-β dysregulation may contribute to (1) the fetal origins of PCOS, (2) reproductive abnormalities in PCOS, and (3) cardiovascular and metabolic abnormalities in PCOS.
dc.description.statementofresponsibilityNazia Raja-Khan, Margrit Urbanek, Raymond J. Rodgers, and Richard S. Legro
dc.identifier.citationReproductive Sciences, 2014; 21(1):20-31
dc.identifier.doi10.1177/1933719113485294
dc.identifier.issn1933-7191
dc.identifier.issn1933-7205
dc.identifier.orcidRodgers, R. [0000-0002-2139-2969]
dc.identifier.urihttp://hdl.handle.net/2440/80549
dc.language.isoen
dc.publisherSage Publications
dc.rights© The Author(s) 2013
dc.source.urihttps://doi.org/10.1177/1933719113485294
dc.subjectpolycystic ovary syndrome
dc.subjectTGF-β
dc.subjectfibrillin
dc.subjectgenetics
dc.subjectfetal origins
dc.titleThe role of TGF-β in polycystic ovary syndrome
dc.title.alternativeThe role of TGF-beta in polycystic ovary syndrome
dc.typeJournal article
pubs.publication-statusPublished

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