Oral and parenteral immunization with synthetic retro-inverso peptides induce antibodies that cross-react with native peptides and parent antigens
| dc.contributor.author | Fischer, Peter | en |
| dc.contributor.author | Comis, Alfio | en |
| dc.contributor.author | Tyler, Margaret | en |
| dc.contributor.author | Howden, Merlin | en |
| dc.contributor.school | School of Molecular and Biomedical Science | en |
| dc.date.issued | 2007 | en |
| dc.description.abstract | The objective of this study was to determine whether certain retro-inverso peptides have the potential to act as synthetic vaccines in mice, when immunized by injection or orally. Immunization of mice parenterally with conjugates of three such retro-inverso peptides and orally with the unconjugated peptides elicited generally high titres of anti-peptide antibodies. Antibodies against the same three peptides cross-reacted by binding strongly in ELISA to the native peptides and vice versa, regardless of the mode of immunization. Antibodies against a retro-inverso diphtheria peptide also reacted strongly with diphtheria toxin. Seven of 8 mice, immunized by injection of the conjugate of a retro-inverso derivative of robustoxin [a lethal spider (Atrax robustus) venom toxin] were protected from challenge involving injection with twice the minimum lethal dose of A. robustus venom containing the toxin. | en |
| dc.description.statementofresponsibility | Peter Fischer, Alfio Comis, Margaret Tyler and Merlin Howden | en |
| dc.description.uri | http://www.niscair.res.in/ScienceCommunication/ResearchJournals/rejour/ijbb/ijbb2k7/ijbb_june07.asp#a2 | en |
| dc.identifier.citation | Indian Journal of Biochemistry and Biophysics, 2007; 44 (3):140-144 | en |
| dc.identifier.issn | 0301-1208 | en |
| dc.identifier.uri | http://hdl.handle.net/2440/45252 | |
| dc.publisher | National Institute of Science Communication and Information Resources, CSIR | en |
| dc.title | Oral and parenteral immunization with synthetic retro-inverso peptides induce antibodies that cross-react with native peptides and parent antigens | en |
| dc.type | Journal article | en |