Global pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050

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dc.contributor.authorJin, Y.
dc.contributor.authorGuo, C.
dc.contributor.authorAbbasian, M.
dc.contributor.authorAbbasifard, M.
dc.contributor.authorAbbott, J.H.
dc.contributor.authorAbdullahi, A.
dc.contributor.authorAbedi, A.
dc.contributor.authorAbidi, H.
dc.contributor.authorAbolhassani, H.
dc.contributor.authorAbu-Gharbieh, E.
dc.contributor.authorAburuz, S.
dc.contributor.authorAbu-Zaid, A.
dc.contributor.authorAddo, I.Y.
dc.contributor.authorAdegboye, O.A.
dc.contributor.authorAdepoju, A.V.
dc.contributor.authorAdikusuma, W.
dc.contributor.authorAdnani, Q.E.S.
dc.contributor.authorAghamiri, S.
dc.contributor.authorAhmad, D.
dc.contributor.authorAhmed, A.
dc.contributor.authoret al.
dc.date.issued2024
dc.description.abstractBackground: This study aims to estimate the burden, trends, forecasts, and disparities of early musculoskeletal (MSK) disorders among individuals ages 15 to 39 years. Methods: The global prevalence, years lived with disabilities (YLDs), disability-adjusted life years (DALYs), projection, and inequality were estimated for early MSK diseases, including rheumatoid arthritis (RA), osteoarthritis (OA), low back pain (LBP), neck pain (NP), gout, and other MSK diseases (OMSKDs). Findings: More adolescents and young adults were expected to develop MSK disorders by 2050. Across five age groups, the rates of prevalence, YLDs, and DALYs for RA, NP, LBP, gout, and OMSKDs sharply increased from ages 15-19 to 35-39; however, these were negligible for OA before age 30 but increased notably at ages 30-34, rising at least 6-fold by 35-39. The disease burden of gout, LBP, and OA attributable to high BMI and gout attributable to kidney dysfunction increased, while the contribution of smoking to LBP and RA and occupational ergonomic factors to LBP decreased. Between 1990 and 2019, the slope index of inequality increased for six MSK disorders, and the relative concentration index increased for gout, NP, OA, and OMSKDs but decreased for LBP and RA. Conclusions: Multilevel interventions should be initiated to prevent disease burden related to RA, NP, LBP, gout, and OMSKDs among individuals ages 15-19 and to OA among individuals ages 30-34 to tightly control high BMI and kidney dysfunction Funding: The Global Burden of Disease study is funded by the Bill and Melinda Gates Foundation. The project is funded by the Scientific Research Fund of Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (2022QN38).
dc.description.statementofresponsibilityGBD 2019 MSK in Adolescents Collaborators
dc.identifier.citationMed, 2024; 5(8):943-962
dc.identifier.doi10.1016/j.medj.2024.04.009
dc.identifier.issn2666-6359
dc.identifier.issn2666-6340
dc.identifier.urihttps://hdl.handle.net/2440/142559
dc.language.isoen
dc.publisherElsevier BV
dc.rights© 2024 The Author. Published by Elsevier Inc. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
dc.source.urihttp://dx.doi.org/10.1016/j.medj.2024.04.009
dc.subjectGBD 2019 MSK in Adolescents Collaborators
dc.subjectHumans
dc.subjectMusculoskeletal Diseases
dc.subjectArthritis, Rheumatoid
dc.subjectGout
dc.subjectOsteoarthritis
dc.subjectLow Back Pain
dc.subjectNeck Pain
dc.subjectPrevalence
dc.subjectForecasting
dc.subjectAdolescent
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.subjectHealth Status Disparities
dc.subjectYoung Adult
dc.subjectGlobal Health
dc.subjectGlobal Burden of Disease
dc.subjectDisability-Adjusted Life Years
dc.subject.meshHumans
dc.subject.meshMusculoskeletal Diseases
dc.subject.meshArthritis, Rheumatoid
dc.subject.meshGout
dc.subject.meshOsteoarthritis
dc.subject.meshLow Back Pain
dc.subject.meshNeck Pain
dc.subject.meshPrevalence
dc.subject.meshForecasting
dc.subject.meshAdolescent
dc.subject.meshAdult
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshHealth Status Disparities
dc.subject.meshYoung Adult
dc.subject.meshGlobal Health
dc.subject.meshGlobal Burden of Disease
dc.subject.meshDisability-Adjusted Life Years
dc.titleGlobal pattern, trend, and cross-country inequality of early musculoskeletal disorders from 1990 to 2019, with projection from 2020 to 2050
dc.typeJournal article
pubs.publication-statusPublished

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