Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation
Date
2013
Authors
Kok, C.
Watkins, D.
Leclercq, T.
D'Andrea, R.
Hughes, T.
White, D.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Leukemia, 2013; 27(6):1427-1430
Statement of Responsibility
CH Kok, DB Watkins, T Leclercq, RJ D’Andrea, TP Hughes and DL White
Conference Name
Abstract
Chronic myeloid leukemia (CML) is characterized by the BCR-ABL1 fusion gene, resulting in uncontrolled proliferation of myeloid progenitor cells. Growth factor independence 1 (GFI1) is a transcription factor with a crucial role in haematopoiesis, including preserving haematopoietic stem cell (HSC) quiescence and enhancing granulocytic differentiation, but is not required for inducing myeloid differentiation in p210BCR/ABL-transformed cells. Recently, Soliera et al.2 demonstrated that ectopic GFI1 expression inhibited proliferation and colony formation both in p210BCR/ABL-expressing cell lines and in primary CD34+ CML cells through the repression of STAT5B and/or Mcl-1.
School/Discipline
Dissertation Note
Provenance
Description
Letter to the Editor
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© 2013 Macmillan Publishers Limited