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Low GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation

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dc.contributor.authorKok, C.
dc.contributor.authorWatkins, D.
dc.contributor.authorLeclercq, T.
dc.contributor.authorD'Andrea, R.
dc.contributor.authorHughes, T.
dc.contributor.authorWhite, D.
dc.date.issued2013
dc.descriptionLetter to the Editor
dc.description.abstractChronic myeloid leukemia (CML) is characterized by the BCR-ABL1 fusion gene, resulting in uncontrolled proliferation of myeloid progenitor cells. Growth factor independence 1 (GFI1) is a transcription factor with a crucial role in haematopoiesis, including preserving haematopoietic stem cell (HSC) quiescence and enhancing granulocytic differentiation, but is not required for inducing myeloid differentiation in p210BCR/ABL-transformed cells. Recently, Soliera et al.2 demonstrated that ectopic GFI1 expression inhibited proliferation and colony formation both in p210BCR/ABL-expressing cell lines and in primary CD34+ CML cells through the repression of STAT5B and/or Mcl-1.
dc.description.statementofresponsibilityCH Kok, DB Watkins, T Leclercq, RJ D’Andrea, TP Hughes and DL White
dc.identifier.citationLeukemia, 2013; 27(6):1427-1430
dc.identifier.doi10.1038/leu.2013.47
dc.identifier.issn0887-6924
dc.identifier.issn1476-5551
dc.identifier.orcidKok, C. [0000-0002-3181-7852]
dc.identifier.orcidHughes, T. [0000-0002-0910-3730] [0000-0002-7990-4509]
dc.identifier.orcidWhite, D. [0000-0003-4844-333X]
dc.identifier.urihttp://hdl.handle.net/2440/79269
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights© 2013 Macmillan Publishers Limited
dc.source.urihttps://doi.org/10.1038/leu.2013.47
dc.subjectcell proliferation
dc.subjectDNA-binding proteins
dc.subjectleukemia
dc.subjectmyelogenous
dc.subjectchronic
dc.subjectBCR-ABL positive
dc.subjectProto-Oncogene Proteins c-bcl-2
dc.subjectSTAT5 transcription factor
dc.subjecttranscription factors
dc.titleLow GFI1 expression in white blood cells of CP-CML patients at diagnosis is strongly associated with subsequent blastic transformation
dc.typeJournal article
pubs.publication-statusPublished

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