Structure revision of meroterpenoid natural products enabled by biomimetic total synthesis

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dc.contributor.authorGeorge, J.H.
dc.date.issued2025
dc.description.abstractMeroterpenoids constitute a vast and structurally diverse family of natural products with mixed biosynthetic origins, found across nearly all forms of life on Earth. Despite their often intricate architectures, meroterpenoid biosynthesis follows a remarkably consistent and predictable chemical logic, driven largely by interactions between electron-rich aromatic rings and terpene-derived building blocks. However, the structural elucidation of these stereochemically complex molecules remains challenging, and misassignments are common. This review highlights the pivotal role of biomimetic total synthesis in enabling the structural reassignment of meroterpenoids, whilst also rationalising their biosynthetic origin, inspiring the design of novel cascade reactions, and even guiding the prediction and discovery of previously unknown natural products.
dc.description.statementofresponsibilityJonathan H. George
dc.identifier.citationChemical Communications, 2025; 61(79):15333-15345
dc.identifier.doi10.1039/d5cc04296h
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.orcidGeorge, J.H. [0000-0002-7330-2160]
dc.identifier.urihttps://hdl.handle.net/2440/148076
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.relation.granthttp://purl.org/au-research/grants/arc/DE130100689
dc.relation.granthttp://purl.org/au-research/grants/arc/DP160103393
dc.relation.granthttp://purl.org/au-research/grants/arc/DP200102964
dc.relation.granthttp://purl.org/au-research/grants/arc/FT170100437
dc.rightsThis journal is © The Royal Society of Chemistry 2025. This article is licensed under a Creative Commons Attribution 3.0 Unported Licence.
dc.source.urihttps://doi.org/10.1039/d5cc04296h
dc.subjectmeroterpenoid natural products; biomimetic total synthesis
dc.subject.meshTerpenes
dc.subject.meshBiological Products
dc.subject.meshBiomimetics
dc.subject.meshMolecular Structure
dc.subject.meshStereoisomerism
dc.subject.meshBiomimetic Materials
dc.titleStructure revision of meroterpenoid natural products enabled by biomimetic total synthesis
dc.typeJournal article
pubs.publication-statusPublished online

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