Impaired working memory in children with attention deficit hyperactivity disorder and their siblings

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dc.contributor.authorWee, Kok Weien
dc.contributor.authorYaacob, Mohd Jamilen
dc.contributor.authorAbdullah, Wan Norhaida Wanen
dc.contributor.authorNakaria, Norzillaen
dc.contributor.authorPridmore, Saxbyen
dc.contributor.schoolSchool of Medicine : Psychiatryen
dc.date.issued2010en
dc.description.abstractIntroduction: Impairment of working memory in children with attention deficit hyperactivity disorder (ADHD) has been well described. If similar impairment in working memory can be demonstrated among their siblings, this could suggest impaired working memory is a genetic component of ADHD. Methods: Fifty-seven subjects were recruited: (1) ADHD group (n=21); (2) siblings of ADHD children group (n=15); and (3) non-ADHD children with chronic medical condition as the control group (n=21). All subjects were aged between 6 and 15 years, and ADHD was diagnosed according to DSM-IV-TR. Those with other comorbidity or IQ<70 were excluded. Digit Recall was used for assessment of the phonological loop component, Maze Memory test for the visuospatial sketch pad component and Backward Digit Recall for the central executive component of working memory. Results: ADHD children and their siblings showed similar impairment and both differed from the control group on the Maze Memory test. ADHD children also showed impairment in the Digit Recall test; however, the sibling group did not differ from the control group on this test. The Backward Digit Recall score did not show any significant difference between the three groups. Discussion: Impairment of the visuospatial sketch pad component of working memory seems to cluster in ADHD children and their siblings. Thus, impairment of the visuospatial sketch pad component of working memory may point towards a genetic predisposition of ADHD.en
dc.description.statementofresponsibilityKok Wei Wee, Mohd Jamil Yaacob, Wan Norhaida Wan Abdullah, Norzila Nakaria, Saxby Pridmoreen
dc.identifier.citationAsia-Pacific Psychiatry, 2010; 2(3):146-150en
dc.identifier.doi10.1111/j.1758-5872.2010.00078.xen
dc.identifier.issn1758-5864en
dc.identifier.urihttp://hdl.handle.net/2440/63622
dc.language.isoenen
dc.publisherWiley-Blackwell Publishing Asiaen
dc.rightsCopyright © 2010 Blackwell Publishing Asia Pty Ltd.en
dc.subjectattention deficit hyperactivity disorder; endophenotype; visuospatial; working memoryen
dc.titleImpaired working memory in children with attention deficit hyperactivity disorder and their siblingsen
dc.typeJournal articleen

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