Relationship between obstructive sleep apnea and diurnal leptin rhythms

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dc.contributor.authorPatel, S.R.
dc.contributor.authorPalmer, L.J.
dc.contributor.authorLarkin, E.K.
dc.contributor.authorJenny, N.S.
dc.contributor.authorWhite, D.P.
dc.contributor.authorRedline, S.
dc.date.issued2004
dc.description.abstractSTUDY OBJECTIVES:Several studies have reported an association between obstructive sleep apnea and leptin, a hormone that influences satiety and body weight. We evaluated the relationship of leptin levels and the overnight change in levels with sleep apnea. DESIGN:Cross-sectional analysis of data from a prospective cohort study. SETTING:Case Western Reserve University General Clinical Research Center. PATIENTS OR PARTICIPANTS:A total of 138 individuals participating in the Cleveland Family Study--59% women, 45% African-American, with mean apnea-hypopnea index (AHI) of 6.9 (range 0-106)--were studied. INTERVENTIONS:None. MEASUREMENTS AND RESULTS:Serum leptin was measured at 10:00 pm to 11:00 pm and at 7:00 am to 8:00 am. Leptin levels in both the morning and evening were positively correlated with apnea-hypopnea index (AHI) in age-, sex-, and race-adjusted analyses (P < .0001) but not after additional adjustment for body mass index. The evening/morning leptin ratio, however, was associated with AHI independent of age, sex, race, body mass index, and waist-hip ratio (P = .03). Conversely, AHI was an independent predictor of the leptin ratio (P = .001) and more predictive than arousal index, oxygenation indices, time asleep, or sleep-stage distribution. An AHI > 15 was associated with a 23% increase in leptin ratio. CONCLUSIONS:These findings suggest that sleep apnea may suppress secretion of leptin in the morning. Alternatively, the relative elevation in evening leptin may influence apnea pathogenesis.
dc.description.statementofresponsibilitySanjay R. Patel, Lyle J. Palmer, Emma K. Larkin, Nancy S. Jenny, David P. White, Susan Redline
dc.identifier.citationSleep, 2004; 27(2):235-239
dc.identifier.doi10.1093/sleep/27.2.235
dc.identifier.issn0161-8105
dc.identifier.issn1550-9109
dc.identifier.orcidPalmer, L.J. [0000-0002-1628-3055]
dc.identifier.urihttp://hdl.handle.net/2440/122525
dc.language.isoen
dc.publisherOxford University Press
dc.rightsCopyright status unknown
dc.source.urihttps://doi.org/10.1093/sleep/27.2.235
dc.subjectObstructive sleep apnea; leptin; obesity
dc.titleRelationship between obstructive sleep apnea and diurnal leptin rhythms
dc.typeJournal article
pubs.publication-statusPublished

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