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Intestinal absorption of fluorescently labeled nanoparticles

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dc.contributor.authorSimovic, S.
dc.contributor.authorSong, Y.
dc.contributor.authorNann, T.
dc.contributor.authorDesai, A.T.
dc.date.issued2015
dc.description.abstractCharacterization of intestinal absorption of nanoparticles is critical in the design of noninvasive anticancer, protein-based, and genenanoparticle-based therapeutics. Here we demonstrate a general approach for the characterization of the intestinal absorption of nanoparticles and for understanding the mechanisms active in their processing within healthy intestinal cells. It is generally accepted that the cellular processing represents a major drawback of current nanoparticle-based therapeutic systems. In particular, endolysosomal trafficking causes degradation of therapeutic molecules such as proteins, lipids, acid-sensitive anticancer drugs, and genes. To date, investigations into nanoparticle processing within intestinal cells have studied mass transport through Caco-2 cells or everted rat intestinal sac models. We developed an approach to visualize directly the mechanisms of nanoparticle processing within intestinal tissue. These results clearly identify a mechanism by which healthy intestinal cells process nanoparticles and point to the possible use of this approach in the design of noninvasive nanoparticle-based therapies.
dc.identifier.citationNanomedicine: Nanotechnology, Biology, and Medicine, 2015; 11(5):1169-1178
dc.identifier.doi10.1016/j.nano.2015.02.016
dc.identifier.issn1549-9634
dc.identifier.issn1549-9642
dc.identifier.urihttps://hdl.handle.net/11541.2/119424
dc.language.isoen
dc.publisherElsevier
dc.relation.fundingCancer Council
dc.relation.fundingSouth Australian Health and Research Institute and National Institutes of Health (NIH) EBO18842
dc.rightsCopyright 2015 Elsevier Access Condition Notes: Postprint only available on Open Access
dc.source.urihttps://doi.org/10.1016/j.nano.2015.02.016
dc.subjectcancer
dc.subjectendocytosis
dc.subjectnanomaterials
dc.subjectnanoparticles
dc.subjectnanotechnology
dc.titleIntestinal absorption of fluorescently labeled nanoparticles
dc.typeJournal article
pubs.publication-statusPublished
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