Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake
Date
2023
Authors
Liu, K.
Liu, B.
Wittert, G.A.
Thompson, C.H.
Hutchison, A.T.
Heilbronn, L.K.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Obesity Research and Clinical Practice, 2023; 17(1):91-93
Statement of Responsibility
Kai Liu, Bo Liu, Gary A. Wittert, Campbell H. Thompson, Amy T. Hutchison, Leonie K. Heilbronn
Conference Name
Abstract
Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2–9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.
School/Discipline
Dissertation Note
Provenance
Description
Available online 9 December 2022
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Rights
© 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.