Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

Date

2023

Authors

Liu, K.
Liu, B.
Wittert, G.A.
Thompson, C.H.
Hutchison, A.T.
Heilbronn, L.K.

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Journal article

Citation

Obesity Research and Clinical Practice, 2023; 17(1):91-93

Statement of Responsibility

Kai Liu, Bo Liu, Gary A. Wittert, Campbell H. Thompson, Amy T. Hutchison, Leonie K. Heilbronn

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Abstract

Growth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2–9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.

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Dissertation Note

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Available online 9 December 2022

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© 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.

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