Intermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake

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dc.contributor.authorLiu, K.
dc.contributor.authorLiu, B.
dc.contributor.authorWittert, G.A.
dc.contributor.authorThompson, C.H.
dc.contributor.authorHutchison, A.T.
dc.contributor.authorHeilbronn, L.K.
dc.date.issued2023
dc.descriptionAvailable online 9 December 2022
dc.description.abstractGrowth differentiation factor 15 (GDF15) increases with acute fast in animals, and high GDF15 reduces food intake in rodents. We explored whether GDF15 was altered following intermittent fasting (IF) versus caloric restriction (CR), and associations with energy intake. Females with obesity received all foods at 70% (IF70 and CR70) or 100% of energy requirements for 8 weeks. IF ate 2–9% less than provided on refeeding days, resulting in greater weight losses. GDF15 was increased 5% more in IF70 versus CR70, but not associated with energy intake. This rise in GDF15 is unlikely to explain restriction of energy intake during IF.
dc.description.statementofresponsibilityKai Liu, Bo Liu, Gary A. Wittert, Campbell H. Thompson, Amy T. Hutchison, Leonie K. Heilbronn
dc.identifier.citationObesity Research and Clinical Practice, 2023; 17(1):91-93
dc.identifier.doi10.1016/j.orcp.2022.12.001
dc.identifier.issn1871-403X
dc.identifier.issn1878-0318
dc.identifier.orcidLiu, K. [0000-0003-3633-1226]
dc.identifier.orcidLiu, B. [0000-0003-3101-650X]
dc.identifier.orcidWittert, G.A. [0000-0001-6818-6065]
dc.identifier.orcidThompson, C.H. [0000-0002-5164-3327]
dc.identifier.orcidHutchison, A.T. [0000-0002-6393-3671]
dc.identifier.orcidHeilbronn, L.K. [0000-0003-2106-7303]
dc.identifier.urihttps://hdl.handle.net/2440/137410
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1023401
dc.rights© 2022 Asia Oceania Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.
dc.source.urihttps://doi.org/10.1016/j.orcp.2022.12.001
dc.subjectGrowth differentiation factor 15; Intermittent fasting; Calorie restriction; Humans; Female
dc.titleIntermittent fasting increases growth differentiation factor 15 in females with overweight or obesity but not associated with food intake
dc.typeJournal article
pubs.publication-statusPublished

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