Effects of co-ingesting glucose and whey protein on blood glucose, plasma insulin and glucagon concentrations, and gastric emptying, in older men with and without type 2 diabetes

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dc.contributor.authorOberoi, A.
dc.contributor.authorGiezenaar, C.
dc.contributor.authorRigda, R.
dc.contributor.authorJones, K.
dc.contributor.authorHorowitz, M.
dc.contributor.authorChapman, I.
dc.contributor.authorSoenen, S.
dc.date.issued2023
dc.description.abstractAim: To investigate whether co-ingestion of dietary protein with, or before, carbohydrate may be a useful strategy to reduce postprandial hyperglycaemia in older men with type 2 diabetes (T2D). Materials and Methods: Blood glucose, plasma insulin and glucagon concentrations were measured for 180 minutes following ingestion of a drink containing 30 g of glucose (G; 120 kcal), 30 g of whey protein (120 kcal), 30 g of glucose plus 30 g of whey protein (GP; 240 kcal), or control (~2 kcal) in older men with T2D (n = 10, 77 ± 1 years; 31 ± 1.7 kg/m2) and without T2D (n = 10, 78 ± 2 years; 27 ± 1.4 kg/m2). Mixed model analysis was used. Results: GP versus G markedly reduced the increase in blood glucose concentrations (P < .001) and had a synergistic effect on the increase in insulin concentrations (P < .001), in men both with and without T2D. Glucose concentrations were higher in men with T2D compared with those without T2D, whereas insulin and glucagon concentrations were largely unaffected by the presence of T2D. Gastric emptying was faster in men with T2D than in those without T2D. Conclusions: The ability of whey protein to reduce carbohydrate-induced, postprandial hyperglycaemia is retained in older men with T2D compared with those without T2D, and whey protein supplementation may be a useful strategy in the prevention and management of T2D in older people.
dc.description.statementofresponsibilityAvneet Oberoi, Caroline Giezenaar, Rachael S. Rigda, Michael Horowitz, Karen L. Jones, Ian Chapman, Stijn Soenen
dc.identifier.citationDiabetes, Obesity and Metabolism, 2023; 25(5):1321-1330
dc.identifier.doi10.1111/dom.14983
dc.identifier.issn1462-8902
dc.identifier.issn1463-1326
dc.identifier.orcidOberoi, A. [0000-0003-0517-8257]
dc.identifier.orcidGiezenaar, C. [0000-0001-5612-1918]
dc.identifier.orcidJones, K. [0000-0002-1155-5816]
dc.identifier.orcidHorowitz, M. [0000-0002-0942-0306]
dc.identifier.orcidSoenen, S. [0000-0002-0196-128X]
dc.identifier.urihttps://hdl.handle.net/2440/142905
dc.language.isoen
dc.publisherWiley
dc.rights© 2023 The Authors. Diabetes, Obesity and Metabolism published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.
dc.source.urihttps://doi.org/10.1111/dom.14983
dc.subjectblood glucose; clinical trial; glucagon; insulin; insulin therapy; dietary intervention; type 2 diabetes; type 2 diabetes and aging
dc.subject.meshHumans
dc.subject.meshDiabetes Mellitus, Type 2
dc.subject.meshHyperglycemia
dc.subject.meshGlucagon
dc.subject.meshInsulin
dc.subject.meshGlucose
dc.subject.meshBlood Glucose
dc.subject.meshGastric Emptying
dc.subject.meshPostprandial Period
dc.subject.meshAged
dc.subject.meshMale
dc.subject.meshGlucagon-Like Peptide 1
dc.subject.meshWhey Proteins
dc.titleEffects of co-ingesting glucose and whey protein on blood glucose, plasma insulin and glucagon concentrations, and gastric emptying, in older men with and without type 2 diabetes
dc.typeJournal article
pubs.publication-statusPublished

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