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Switching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivity

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dc.contributor.authorDaniels, J.
dc.contributor.authorMcFarlane, A.
dc.contributor.authorBluhm, R.
dc.contributor.authorMoores, K.
dc.contributor.authorClark, C.
dc.contributor.authorShaw, M.
dc.contributor.authorWilliamson, P.
dc.contributor.authorDensmore, M.
dc.contributor.authorLanius, R.
dc.date.issued2010
dc.description.abstract<h4>Unlabelled</h4>Working memory processing and resting-state connectivity in the default mode network are altered in patients with posttraumatic stress disorder (PTSD). Because the ability to effortlessly switch between concentration on a task and an idling state during rest is implicated in both these alterations, we undertook a functional magnetic resonance imaging study with a block design to analyze task-induced modulations in connectivity.<h4>Methods</h4>We performed a working memory task and psychophysiologic interaction analyses with the posterior cingulate cortex and the medial prefrontal cortex as seed regions during fixation in 12 patients with severe, chronic PTSD and 12 healthy controls.<h4>Results</h4>During the working memory task, the control group showed significantly stronger connectivity with areas implicated in the salience and executive networks, including the right inferior frontal gyrus and the right inferior parietal lobule. The PTSD group showed stronger connectivity with areas implicated in the default mode network, namely enhanced connectivity between the posterior cingulate cortex and the right superior frontal gyrus and between the medial prefrontal cortex and the left parahippocampal gyrus.<h4>Limitations</h4>Because we were studying alterations in patients with severe, chronic PTSD, we could not exclude patients taking medication. The small sample size may have limited the power of our analyses. To avoid multiple testing in a small sample, we only used 2 seed regions for our analyses.<h4>Conclusion</h4>The different patterns of connectivity imply significant group differences with task-induced switches (i.e., engaging and disengaging the default mode network and the central-executive network).
dc.description.statementofresponsibilityJudith K. Daniels, Alexander C. McFarlane, Robyn L. Bluhm, Kathryn A. Moores, C. Richard Clark, Marnie E. Shaw, Peter C. Williamson, Maria Densmore, Ruth A. Lanius
dc.identifier.citationJournal of Psychiatry and Neuroscience, 2010; 35(4):258-266
dc.identifier.doi10.1503/jpn.090175
dc.identifier.issn1180-4882
dc.identifier.issn1488-2434
dc.identifier.orcidMcFarlane, A. [0000-0002-3829-9509]
dc.identifier.urihttp://hdl.handle.net/2440/61734
dc.language.isoen
dc.publisherCanadian Medical Association
dc.rights© 2010 Canadian Medical Association
dc.source.urihttps://doi.org/10.1503/jpn.090010
dc.subjectGyrus Cinguli
dc.subjectParahippocampal Gyrus
dc.subjectPrefrontal Cortex
dc.subjectParietal Lobe
dc.subjectNerve Net
dc.subjectHumans
dc.subjectMagnetic Resonance Imaging
dc.subjectMemory, Short-Term
dc.subjectStress Disorders, Post-Traumatic
dc.subjectPsychiatric Status Rating Scales
dc.subjectAdult
dc.subjectMiddle Aged
dc.subjectFemale
dc.subjectMale
dc.subjectExecutive Function
dc.titleSwitching between executive and default mode networks in posttraumatic stress disorder: alterations in functional connectivity
dc.typeJournal article
pubs.publication-statusPublished

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