Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut
Date
2007
Authors
Wilson, D.
Mattapallil, J.
Lay, M.
Zhang, L.
Roederer, M.
Davenport, M.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Journal of Virology, 2007; 81(15):8025-8029
Statement of Responsibility
David P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport
Conference Name
Abstract
CD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
School/Discipline
Dissertation Note
Provenance
Published ahead of print on 16 May 2007.
Description
Access Status
Rights
© 2007, American Society for Microbiology. All Rights Reserved.