Estimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut

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dc.contributor.authorWilson, D.
dc.contributor.authorMattapallil, J.
dc.contributor.authorLay, M.
dc.contributor.authorZhang, L.
dc.contributor.authorRoederer, M.
dc.contributor.authorDavenport, M.
dc.date.issued2007
dc.description.abstractCD4+ T-cell depletion during acute human immunodeficiency virus infection occurs predominantly in the gastrointestinal mucosa. Using experimental data on SIV(mac251) viral load in blood and CD4+ T cells in the jejunum, we modeled the kinetics of CD4+ T-cell infection and death and estimated the viral infectivity. The infectivity of SIV(mac251) is higher than previously estimated for SHIV89.6P infection, but this higher infectivity is offset by a lower average peak viral load in SIV(mac251). Thus, the dynamics of target cell infection and death are remarkably similar between a CXCR4- and a CCR5-tropic infection in vivo.
dc.description.statementofresponsibilityDavid P. Wilson, Joseph J. Mattapallil, Matthew D. H. Lay, Lei Zhang, Mario Roederer and Miles P. Davenport
dc.identifier.citationJournal of Virology, 2007; 81(15):8025-8029
dc.identifier.doi10.1128/JVI.01771-06
dc.identifier.issn0022-538X
dc.identifier.issn1098-5514
dc.identifier.urihttp://hdl.handle.net/2440/44836
dc.language.isoen
dc.provenancePublished ahead of print on 16 May 2007.
dc.publisherAmer Soc Microbiology
dc.rights© 2007, American Society for Microbiology. All Rights Reserved.
dc.source.urihttps://doi.org/10.1128/jvi.01771-06
dc.subjectGastrointestinal Tract
dc.subjectCD4-Positive T-Lymphocytes
dc.subjectAnimals
dc.subjectMacaca mulatta
dc.subjectHumans
dc.subjectSimian Acquired Immunodeficiency Syndrome
dc.subjectReceptors, CCR5
dc.subjectViral Load
dc.subjectMathematics
dc.subjectModels, Theoretical
dc.subjectSimian immunodeficiency virus
dc.titleEstimating the infectivity of CCR5-tropic simian immunodeficiency virus SIVmac251 in the gut
dc.typeJournal article
pubs.publication-statusPublished

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