The role of platelets in vasculogenic mimicry /
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(Published version)
Date
2017
Authors
Martino, Carmela,
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thesis
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Abstract
Platelets are small megakaryocyte fragments which, while essential in maintaining haemostasis, are also known to be abundant carriers of both pro- and anti-angiogenic components. Platelets play a role in tumour angiogenesis by supporting the development of EC-lined tumour angiogenic vessels, despite their ability to also release anti-angiogenic compounds. Although many studies have investigated the role of platelets in cancer, it is currently unknown whether platelets are also involved in regulating VM by cancer cells.The current study addressed this question by specifically examining the effect of platelets on VM both in vitro and in vivo, as well as elucidating the mechanisms involved. Investigations were conducted using in vitro assays followed by an in vivo model of triple-negative breast cancer (TNBC) in which both normal platelets and those with a functional defect (aspirin administration) were examined.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD(Medical Science))--University of South Australia, 2017.
Provenance
Copyright 2017 Carmela Martino.
Description
1 ethesis (xvi, 273 pages) :
colour illustrations
Includes bibliographical references (pages 225-273)
colour illustrations
Includes bibliographical references (pages 225-273)
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