The role of platelets in vasculogenic mimicry /
| dc.contributor.author | Martino, Carmela, | |
| dc.contributor.school | University of South Australia. School of Pharmacy and Medical Sciences. | |
| dc.contributor.school | School of Pharmacy and Medical Sciences. | |
| dc.date.issued | 2017 | |
| dc.description | 1 ethesis (xvi, 273 pages) : | |
| dc.description | colour illustrations | |
| dc.description | Includes bibliographical references (pages 225-273) | |
| dc.description.abstract | Platelets are small megakaryocyte fragments which, while essential in maintaining haemostasis, are also known to be abundant carriers of both pro- and anti-angiogenic components. Platelets play a role in tumour angiogenesis by supporting the development of EC-lined tumour angiogenic vessels, despite their ability to also release anti-angiogenic compounds. Although many studies have investigated the role of platelets in cancer, it is currently unknown whether platelets are also involved in regulating VM by cancer cells.The current study addressed this question by specifically examining the effect of platelets on VM both in vitro and in vivo, as well as elucidating the mechanisms involved. Investigations were conducted using in vitro assays followed by an in vivo model of triple-negative breast cancer (TNBC) in which both normal platelets and those with a functional defect (aspirin administration) were examined. | |
| dc.description.dissertation | Thesis (PhD(Medical Science))--University of South Australia, 2017. | |
| dc.identifier.uri | https://hdl.handle.net/11541.2/130947 | |
| dc.language.iso | en | |
| dc.provenance | Copyright 2017 Carmela Martino. | |
| dc.subject.lcsh | Blood platelets. | |
| dc.subject.lcsh | Neovascularization inhibitors. | |
| dc.subject.lcsh | Tumors | |
| dc.title | The role of platelets in vasculogenic mimicry / | |
| dc.type | thesis | |
| dcterms.accessRights | 506 0#$fstar $2Unrestricted online access | |
| ror.fileinfo | 12153350780001831 13153350770001831 Martino, Carmela - Thesis_Redacted | |
| ror.mmsid | 9916176561801831 |
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