Unlocking the power of semen analysis in primary health care - a path to men's health and lifestyle transformation.
Date
2025
Authors
Lyons, H.E.
Peel, A.
Gonzalez, M.
Deluao, J.
Olatunji, O.
Nikitaras, V.
McPherson, N.O.
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Journal article
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Nature Reviews Urology, 2025; 22(10):687-702
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Hannah E. Lyons, Andrew Peel, Macarena Gonzalez, Josh Deluao, Oluwabunmi Olatunji, Victoria Nikitaras, Nicole O. McPherson
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Abstract
Declining fertility, overlooked mental health, and reduced life expectancy underscore the urgent need for renewed attention to men’s health. A semen analysis, traditionally used to assess fertility, holds untapped potential as a tool for promoting lifestyle changes and preventing chronic diseases in men. Spermatogenesis is highly sensitive to environmental and lifestyle factors and can be an early indicator of overall health. Disruptions in this process can signal underlying systemic issues and predict long-term health risks, including cardiovascular disease and metabolic disorders. An increasing number of men seek to engage in preconception care, as fertility is closely tied to a man’s sense of masculinity, identity and aspirations for fatherhood. In this context, a semen analysis can be a powerful motivator to encourage healthy behaviours and proactive health management. By incorporating semen analysis into primary care, health care providers can leverage men’s desire for fatherhood as an entry point to discuss broader health concerns, such as mental well-being, nutrition and physical activity. This approach would address immediate reproductive health, and also promote long-term wellness, helping to reduce the burden of chronic disease in men.
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© Springer Nature Limited 2025. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.