Cell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity

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dc.contributor.authorPolara, R.
dc.contributor.authorGanesan, R.
dc.contributor.authorPitson, S.M.
dc.contributor.authorRobinson, N.
dc.date.issued2024
dc.description.abstractCD47 is a ubiquitously expressed cell surface receptor, which is widely known for preventing macrophage-mediated phagocytosis by interacting with signal regulatory protein α (SIRPα) on the surface of macrophages. In addition to its role in phagocytosis, emerging studies have reported numerous noncanonical functions of CD47 that include regulation of various cellular processes such as proliferation, migration, apoptosis, differentiation, stress responses, and metabolism. Despite lacking an extensive cytoplasmic signaling domain, CD47 binds to several cytoplasmic proteins, particularly upon engaging with its secreted matricellular ligand, thrombospondin 1. Indeed, the regulatory functions of CD47 are greatly influenced by its interacting partners. These interactions are often cell- and context-specific, adding a further level of complexity. This review addresses the downstream cell-intrinsic signaling pathways regulated by CD47 in various cell types and environments. Some of the key pathways modulated by this receptor include the PI3K/AKT, MAPK/ERK, and nitric oxide signaling pathways, as well as those implicated in glucose, lipid, and mitochondrial metabolism. These pathways play vital roles in maintaining tissue homeostasis, highlighting the importance of understanding the phagocytosis-independent functions of CD47. Given that CD47 expression is dysregulated in a variety of cancers, improving our understanding of the cell-intrinsic signals regulated by this molecule will help advance the development of CD47-targeted therapies.
dc.description.statementofresponsibilityRuhi Polara, Raja Ganesan, Stuart M. Pitson, and Nirmal Robinson
dc.identifier.citationCell Death and Differentiation, 2024; 31(10):1255-1266
dc.identifier.doi10.1038/s41418-024-01347-w
dc.identifier.issn1350-9047
dc.identifier.issn1476-5403
dc.identifier.orcidPitson, S.M. [0000-0002-9527-2740]
dc.identifier.orcidRobinson, N. [0000-0002-7361-9491]
dc.identifier.urihttps://hdl.handle.net/2440/143112
dc.language.isoen
dc.publisherSpringer Science and Business Media LLC
dc.relation.grantNHMRC
dc.rights© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http:// creativecommons.org/licenses/by/4.0/.
dc.source.urihttp://dx.doi.org/10.1038/s41418-024-01347-w
dc.subjectAnimals
dc.subjectHumans
dc.subjectSignal Transduction
dc.subjectPhagocytosis
dc.subjectCell Plasticity
dc.subjectCD47 Antigen
dc.subject.meshAnimals
dc.subject.meshHumans
dc.subject.meshSignal Transduction
dc.subject.meshPhagocytosis
dc.subject.meshCell Plasticity
dc.subject.meshCD47 Antigen
dc.titleCell autonomous functions of CD47 in regulating cellular plasticity and metabolic plasticity
dc.typeJournal article
pubs.publication-statusPublished

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