A randomized trial comparing repetitive transcranial magnetic stimulation given 3 days/week and 5 days/week for the treatment of major depression: Is efficacy related to the duration of treatment or the number of treatments?

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dc.contributor.authorGalletly, C.
dc.contributor.authorGill, S.
dc.contributor.authorClarke, P.
dc.contributor.authorBurton, C.
dc.contributor.authorFitzgerald, P.
dc.date.issued2012
dc.description.abstractBackground: Repetitive transcranial magnetic stimulation (rTMS) has been shown to be an effective treatment for depression. However, there has been little research to determine optimal parameters for treatment. Method: This study compared two rTMS treatment regimes for the treatment of major depression. Seventy-seven participants were randomized to either spaced or daily treatment. Spaced rTMS was given 3 days/week for 6 weeks (18 treatments in total) and daily rTMS was given 5 days/week for 4 weeks (20 treatments in total). All participants were assessed at baseline and after 4 weeks of treatment. Participants in the spaced treatment group were also assessed after 6 weeks of treatment. All participants were treated at 110% of the resting motor threshold with high-frequency rTMS (10 Hz) to the left dorsolateral prefrontal cortex (DLPFC) followed by low-frequency rTMS to the right DLPFC. Results: Participants in the daily treatment group showed more improvement by week 4 than those in the spaced treatment group; however, both groups had similar improvement by treatment completion. There was significant improvement in both groups in ratings of depression and anxiety, with no significant differences between groups. Conclusions: Our study indicates that the efficacy of rTMS is related to the number of treatments given and that spacing the treatments neither improves nor reduces efficacy.
dc.description.statementofresponsibilityC. Galletly, S. Gill, P. Clarke, C. Burton and P. B. Fitzgerald
dc.identifier.citationPsychological Medicine, 2012; 42(5):981-988
dc.identifier.doi10.1017/S0033291711001760
dc.identifier.issn1469-8978
dc.identifier.issn1469-8978
dc.identifier.orcidGalletly, C. [0000-0001-6185-9677]
dc.identifier.orcidGill, S. [0000-0001-7180-1807]
dc.identifier.urihttp://hdl.handle.net/2440/71825
dc.language.isoen
dc.publisherCambridge University Press
dc.relation.grantNHMRC
dc.rightsCopyright © Cambridge University Press 2011
dc.source.urihttps://doi.org/10.1017/s0033291711001760
dc.subjectAntidepressant
dc.subjectdorsolateral prefrontal cortex
dc.subjecthigh-frequency stimulation
dc.subjectneurostimulation
dc.subjecttreatment service
dc.titleA randomized trial comparing repetitive transcranial magnetic stimulation given 3 days/week and 5 days/week for the treatment of major depression: Is efficacy related to the duration of treatment or the number of treatments?
dc.typeJournal article
pubs.publication-statusPublished

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