Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human.
Date
1995
Authors
Knights, K.
McLean, C.
Tonkin, A.
Miners, J.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
British Journal of Clinical Pharmacology, 1995; 40(2):153-156
Statement of Responsibility
Knights, Km ; Mclean, Cf ; Tonkin, Al ; Miners, Jo
Conference Name
Abstract
The effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion.