Lack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human.

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dc.contributor.authorKnights, K.
dc.contributor.authorMcLean, C.
dc.contributor.authorTonkin, A.
dc.contributor.authorMiners, J.
dc.date.issued1995
dc.description.abstractThe effects of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen were studied in groups of healthy adult males, females and oral contraceptive steroid (OCS) using females. The values of AUC, CLpo, t1/2 and Vss, app did not differ significantly between the groups. Similarly, the percentage unbound of (R)-ibuprofen in pooled plasma from the three groups was not statistically different. Since chiral inversion is the major determinant of (R)-ibuprofen clearance in humans, it may be inferred from these data that gender and OCS have little or no effect on conversion of (R)-ibuprofen to the pharmacologically active S-enantiomer. Moreover, it is unlikely that hormonal factors influence the activity of the human hepatic long-chain fatty-acid:CoA ligase, the enzyme mediating the rate limiting step of (R)-ibuprofen inversion.
dc.description.statementofresponsibilityKnights, Km ; Mclean, Cf ; Tonkin, Al ; Miners, Jo
dc.identifier.citationBritish Journal of Clinical Pharmacology, 1995; 40(2):153-156
dc.identifier.doi10.1111/j.1365-2125.1995.tb05769.x
dc.identifier.issn0306-5251
dc.identifier.issn1365-2125
dc.identifier.urihttp://hdl.handle.net/2440/14328
dc.language.isoen
dc.publisherBlackwell Scientific
dc.source.urihttps://doi.org/10.1111/j.1365-2125.1995.tb05769.x
dc.subjectHumans
dc.subjectIbuprofen
dc.subjectContraceptives, Oral, Hormonal
dc.subjectAnti-Inflammatory Agents, Non-Steroidal
dc.subjectAdministration, Oral
dc.subjectAnalysis of Variance
dc.subjectSex Factors
dc.subjectStereoisomerism
dc.subjectAdolescent
dc.subjectAdult
dc.subjectFemale
dc.subjectMale
dc.titleLack of effect of gender and oral contraceptive steroids on the pharmacokinetics of (R)-ibuprofen in human.
dc.typeJournal article
pubs.publication-statusPublished

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