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Reversing antimicrobial resistance with inhibitors of drug efflux pumps /

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dc.contributor.authorChen, Yang
dc.contributor.schoolUniversity of South Australia. UniSA Clinical and Health Sciences.
dc.contributor.schoolUniSA Clinical and Health Sciences
dc.date.issued2023
dc.description1 ethesis (208 pages) :
dc.descriptioncolour illustrations, charts.
dc.descriptionIncludes bibliographical references (pages 122-130)
dc.description.abstractAntimicrobial resistance is one of the biggest threats to modern medicine and public health according to global organizations such as the World Health Organization. Hence new approaches to combat drug resistant bacteria and address the shortage of new antimicrobials are desperately needed, particularly for Gram-negative bacteria. This research investigated the identification and evaluation of synthetic and repurposed compounds as inhibitors of important resistance mechanisms: the RND efflux pumps in Gram-negative bacteria including the AcrAB-TolC efflux pump in E. coli and MexAB-OprM efflux pump in Pseudomonas. As a result, six compounds among thirty-nine benzo[h]chromene and flavonoid derivatives were identified as putative inhibitors for AcrB. IvacaPor, a transmembrane conductance protein potentiator, was identified as a promising candidate for repurposing as inhibitor for MexB.
dc.description.dissertationThesis (Masters by Research(Medical Science))--University of South Australia, 2023.
dc.identifier.urihttps://hdl.handle.net/11541.2/35817
dc.language.isoen
dc.provenanceCopyright 2023 Yang Chen.
dc.subjectmultidrug resistance;efflux pump inhibitor
dc.subject.lcshAnti-infective agents.
dc.subject.lcshBacteria
dc.subject.lcshGram-negative bacteria
dc.subject.lcshMultidrug resistance.
dc.titleReversing antimicrobial resistance with inhibitors of drug efflux pumps /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12276149860001831 13276149850001831 Chen, Yang - Thesis
ror.mmsid9916798031301831

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