An optimised synthesis of 2-[2,3-Bis(tert -butoxycarbonyl)guanidino] ethylamine
Date
2012
Authors
Hickey, S.M.
Ashton, T.D.
Khosa, S.K.
Pfeffer, F.M.
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Advisors
Journal Title
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Volume Title
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Journal article
Citation
Synlett, 2012; 23(12):1779-1782
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Abstract
This short report describes an improved, reliable, and high-yielding (> 90%) synthesis of 2-[2,3-bis(tert-butoxycarbonyl)guanidino]ethylamine. The method is scalable (> 5 g), and the product obtained directly from the reaction mixture requires no further purification. In addition, this methodology can be successfully applied to other diamine substrates (1,3-propyl and 1,4-butyl; 70% and 61% yield, respectively).
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Dissertation Note
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Data source: Supplementary information, https://www.thieme-connect.de/media/synlett/201212/supmat/sup_st-2012-d0321-l_10-1055_s-0031-1290698.pdf
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Copyright 2012 Georg Thieme Verlag