An optimised synthesis of 2-[2,3-Bis(tert -butoxycarbonyl)guanidino] ethylamine

dc.contributor.author	Hickey, S.M.
dc.contributor.author	Ashton, T.D.
dc.contributor.author	Khosa, S.K.
dc.contributor.author	Pfeffer, F.M.
dc.date.issued	2012
dc.description	Data source: Supplementary information, https://www.thieme-connect.de/media/synlett/201212/supmat/sup_st-2012-d0321-l_10-1055_s-0031-1290698.pdf
dc.description.abstract	This short report describes an improved, reliable, and high-yielding (> 90%) synthesis of 2-[2,3-bis(tert-butoxycarbonyl)guanidino]ethylamine. The method is scalable (> 5 g), and the product obtained directly from the reaction mixture requires no further purification. In addition, this methodology can be successfully applied to other diamine substrates (1,3-propyl and 1,4-butyl; 70% and 61% yield, respectively).
dc.identifier.citation	Synlett, 2012; 23(12):1779-1782
dc.identifier.doi	10.1055/s-0031-1290698
dc.identifier.issn	0936-5214
dc.identifier.issn	1437-2096
dc.identifier.orcid	Hickey, S.M. [0000-0002-3063-531X]
dc.identifier.uri	https://hdl.handle.net/11541.2/118756
dc.language.iso	en
dc.publisher	Georg Thieme Verlag
dc.relation.funding	Deakin University
dc.rights	Copyright 2012 Georg Thieme Verlag
dc.source.uri	https://doi.org/10.1055/s-0031-1290698
dc.subject	guanidine
dc.subject	synthesis
dc.subject	optimisation
dc.subject	cyclisation
dc.subject	protecting groups
dc.subject	NMR spectroscopy
dc.title	An optimised synthesis of 2-[2,3-Bis(tert -butoxycarbonyl)guanidino] ethylamine
dc.type	Journal article
pubs.publication-status	Published
ror.mmsid	9916014711401831

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