Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis
Date
2008
Authors
Leung, H.
Colangelo, H.
Kee, T.
Editors
Advisors
Journal Title
Journal ISSN
Volume Title
Type:
Journal article
Citation
Langmuir: the ACS journal of surfaces and colloids, 2008; 24(11):5672-5675
Statement of Responsibility
Mandy H. M. Leung, Hannah Colangelo and Tak W. Kee
Conference Name
Abstract
The alkaline hydrolysis of curcumin was studied in three types of micelles composed of the cationic surfactants cetyl trimethylammonium bromide (CTAB) and dodecyl trimethylammonium bromide (DTAB) and the anionic surfactant sodium dodecyl sulfate (SDS). At pH 13, curcumin undergoes rapid degradation by alkaline hydrolysis in the SDS micellar solution. In contrast, alkaline hydrolysis of curcumin is greatly suppressed in the presence of either CTAB or DTAB micelles, with a yield of suppression close to 90%. The results from fluorescence spectroscopic studies reveal that while curcumin remains encapsulated in CTAB and DTAB micelles at pH 13, curcumin is dissociated from the SDS micelles to the aqueous phase at this pH. The absence of encapsulation and stabilization in the SDS micellar solution results in rapid hydrolysis of curcumin.
School/Discipline
Dissertation Note
Provenance
Description
Copyright © 2008 American Chemical Society