Encapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis

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dc.contributor.authorLeung, H.
dc.contributor.authorColangelo, H.
dc.contributor.authorKee, T.
dc.date.issued2008
dc.descriptionCopyright © 2008 American Chemical Society
dc.description.abstractThe alkaline hydrolysis of curcumin was studied in three types of micelles composed of the cationic surfactants cetyl trimethylammonium bromide (CTAB) and dodecyl trimethylammonium bromide (DTAB) and the anionic surfactant sodium dodecyl sulfate (SDS). At pH 13, curcumin undergoes rapid degradation by alkaline hydrolysis in the SDS micellar solution. In contrast, alkaline hydrolysis of curcumin is greatly suppressed in the presence of either CTAB or DTAB micelles, with a yield of suppression close to 90%. The results from fluorescence spectroscopic studies reveal that while curcumin remains encapsulated in CTAB and DTAB micelles at pH 13, curcumin is dissociated from the SDS micelles to the aqueous phase at this pH. The absence of encapsulation and stabilization in the SDS micellar solution results in rapid hydrolysis of curcumin.
dc.description.statementofresponsibilityMandy H. M. Leung, Hannah Colangelo and Tak W. Kee
dc.identifier.citationLangmuir: the ACS journal of surfaces and colloids, 2008; 24(11):5672-5675
dc.identifier.doi10.1021/la800780w
dc.identifier.issn0743-7463
dc.identifier.issn1520-5827
dc.identifier.orcidKee, T. [0000-0002-4907-4663]
dc.identifier.urihttp://hdl.handle.net/2440/46368
dc.language.isoen
dc.publisherAmer Chemical Soc
dc.source.urihttp://pubs.acs.org/cgi-bin/abstract.cgi/langd5/2008/24/i11/abs/la800780w.html
dc.subjectSodium Dodecyl Sulfate
dc.subjectCetrimonium Compounds
dc.subjectCurcumin
dc.subjectHydrolysis
dc.subjectMicelles
dc.subjectHydrogen-Ion Concentration
dc.subjectQuaternary Ammonium Compounds
dc.subjectCetrimonium
dc.titleEncapsulation of curcumin in cationic micelles suppresses alkaline hydrolysis
dc.typeJournal article
pubs.publication-statusPublished

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