Pathophysiology of bone marrow micro-vascular system damage and potency of flavonoids in recovery of bone marrow micro-vasculature following methotrexate therapy in rats /
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(Published version)
Date
2017
Authors
Hassanshahi, Mohammadhossein,
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thesis
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Abstract
Chemotherapy and radiotherapy are known as main approaches for cancer treatment. However, it has been very well accepted that chemotherapy and irradiation cause damage to the healthy cells/tissues, leading to emerging some undesired outcomes. Of such, the negative effects of chemotherapy and irradiation on bone marrow (BM) micro-vascular (sinusoids) system have been widely reported. One of the widely used chemotherapeutic agents is methotrexate (MTX) which is used for treatment of many malignancies and inflammatory-related diseases (Minaur, Kounali et al. 2002). MTX has been shown to have many adverse effects on several physiological functions including osteogenesis (Xian, Cool et al. 2007). However, despite its wide use, inadequate attention has been drawn to the negative effect(s) of MTX on BM micro-vascular system and their potential treatments. Therefore, this PhD project attempted to address these questions.
School/Discipline
University of South Australia. School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
School of Pharmacy and Medical Sciences.
Dissertation Note
Thesis (PhD)--University of South Australia, 2017.
Provenance
Copyright 2017 Mohammadhossein Hassanshahi.
Description
1 ethesis (xvi, 168 pages) :
colour illustrations, charts
Includes bibliographical references (pages 130-168)
colour illustrations, charts
Includes bibliographical references (pages 130-168)
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