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Pathophysiology of bone marrow micro-vascular system damage and potency of flavonoids in recovery of bone marrow micro-vasculature following methotrexate therapy in rats /

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dc.contributor.authorHassanshahi, Mohammadhossein,
dc.contributor.schoolUniversity of South Australia. School of Pharmacy and Medical Sciences.
dc.contributor.schoolSchool of Pharmacy and Medical Sciences.
dc.date.issued2017
dc.description1 ethesis (xvi, 168 pages) :
dc.descriptioncolour illustrations, charts
dc.descriptionIncludes bibliographical references (pages 130-168)
dc.description.abstractChemotherapy and radiotherapy are known as main approaches for cancer treatment. However, it has been very well accepted that chemotherapy and irradiation cause damage to the healthy cells/tissues, leading to emerging some undesired outcomes. Of such, the negative effects of chemotherapy and irradiation on bone marrow (BM) micro-vascular (sinusoids) system have been widely reported. One of the widely used chemotherapeutic agents is methotrexate (MTX) which is used for treatment of many malignancies and inflammatory-related diseases (Minaur, Kounali et al. 2002). MTX has been shown to have many adverse effects on several physiological functions including osteogenesis (Xian, Cool et al. 2007). However, despite its wide use, inadequate attention has been drawn to the negative effect(s) of MTX on BM micro-vascular system and their potential treatments. Therefore, this PhD project attempted to address these questions.
dc.description.dissertationThesis (PhD)--University of South Australia, 2017.
dc.identifier.urihttps://hdl.handle.net/11541.2/128727
dc.language.isoen
dc.provenanceCopyright 2017 Mohammadhossein Hassanshahi.
dc.subject.lcshBone marrow
dc.subject.lcshCancer
dc.subject.lcshMicrocirculation.
dc.titlePathophysiology of bone marrow micro-vascular system damage and potency of flavonoids in recovery of bone marrow micro-vasculature following methotrexate therapy in rats /
dc.typethesis
dcterms.accessRights506 0#$fstar $2Unrestricted online access
ror.fileinfo12149597460001831 13149597450001831 Hassanshahi, Mohammadhossein - Thesis
ror.mmsid9916159605301831

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