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The Prospective Association between Early Life Growth and Breast Density in Young Adult Women

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dc.contributor.authorLloyd, R.
dc.contributor.authorPirikahu, S.
dc.contributor.authorWalter, J.
dc.contributor.authorCadby, G.
dc.contributor.authorWarrington, N.
dc.contributor.authorPerera, D.
dc.contributor.authorHickey, M.
dc.contributor.authorSaunders, C.
dc.contributor.authorHackmann, M.
dc.contributor.authorSampson, D.D.
dc.contributor.authorShepherd, J.
dc.contributor.authorLilge, L.
dc.contributor.authorStone, J.
dc.date.issued2024
dc.description.abstractBreast density is a strong intermediate endpoint to investigate the association between early-life exposures and breast cancer risk. This study investigates the association between early-life growth and breast density in young adult women measured using Optical Breast Spectroscopy (OBS) and Dual X-ray Absorptiometry (DXA). OBS measurements were obtained for 536 female Raine Cohort Study participants at ages 27–28, with 268 completing DXA measurements. Participants with three or more height and weight measurements from ages 8 to 22 were used to generate linear growth curves for height, weight and body mass index (BMI) using SITAR modelling. Three growth parameters (size, velocity and timing) were examined for association with breast density measures, adjusting for potential confounders. Women who reached their peak height rapidly (velocity) and later in adolescence (timing) had lower OBS-breast density. Overall, women who were taller (size) had higher OBS-breast density. For weight, women who grew quickly (velocity) and later in adolescence (timing) had higher absolute DXA-breast density. Overall, weight (size) was also inversely associated with absolute DXA-breast density, as was BMI. These findings provide new evidence that adolescent growth is associated with breast density measures in young adult women, suggesting potential mediation pathways for breast cancer risk in later life.
dc.description.statementofresponsibilityRachel Lloyd, Sarah Pirikahu, Jane Walter, Gemma Cadby, Nicole Warrington, Dilukshi Perera, Martha Hickey, Christobel Saunders, Michael Hackmann, David D. Sampson, John Shepherd, Lothar Lilge, and Jennifer Stone
dc.identifier.citationCancers, 2024; 16(13):2418-1-2418-16
dc.identifier.doi10.3390/cancers16132418
dc.identifier.issn2072-6694
dc.identifier.issn2072-6694
dc.identifier.orcidStone, J. [0000-0002-3787-6175] [0000-0002-7848-1401]
dc.identifier.urihttps://hdl.handle.net/2440/143147
dc.language.isoen
dc.publisherMDPI AG
dc.relation.grantNHMRC
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttp://dx.doi.org/10.3390/cancers16132418
dc.subjectbreast density; breast cancer risk; early life growth; optical breast spectroscopy; dual x-ray absorptiometry; the Raine Study
dc.titleThe Prospective Association between Early Life Growth and Breast Density in Young Adult Women
dc.typeJournal article
pubs.publication-statusPublished

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