Changes in gastrointestinal motor and sensory function associated with ageing
Date
2022
Authors
Rayner, C.K.
Horowitz, M.
Editors
Sinclair, A.J.
Morley, J.E.
Vellas, B.
Cesari, M.
Munshi, M.
Morley, J.E.
Vellas, B.
Cesari, M.
Munshi, M.
Advisors
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Book chapter
Citation
Pathy's Principles and Practice of Geriatric Medicine, 2022 / Sinclair, A.J., Morley, J.E., Vellas, B., Cesari, M., Munshi, M. (ed./s), vol.1, Ch.17, pp.231-246
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Christopher K. Rayner, and Michael Horowitz
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Abstract
This chapter reviews the changes in gastrointestinal motor and sensory function associated with healthy ageing and their clinical significance, together with what is known of the underlying causes. The intrinsic sensory neurons, interneurons, and motor neurons that comprise the enteric nervous system control basic contractile activity such as reflex responses to distension. The chapter discusses the illnesses with gastrointestinal complications that are common in the elderly, along with medications that may affect gastrointestinal motility. Particular focus is given to the oesophagus, stomach, and small intestinal motility since oropharyngeal swallowing disorders, the gall bladder, and the colon and anorectum are dealt with elsewhere, as are the mucosal functions of secretion and absorption. Although the effects of healthy ageing per se on gastrointestinal motility are modest, the prevalence of comorbidities that may impact gut function increases markedly with advancing age ; Parkinson's disease and diabetes are typical examples.
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© 2022 John Wiley & Sons Ltd. Published 2022 by John Wiley & Sons Ltd.