Towards multimodal cellular imaging: optical and X-ray fluorescence

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dc.contributor.authorGraziotto, M.E.
dc.contributor.authorKidman, C.J.
dc.contributor.authorAdair, L.D.
dc.contributor.authorJames, S.A.
dc.contributor.authorHarris, H.H.
dc.contributor.authorNew, E.J.
dc.date.issued2023
dc.descriptionFirst published 01 Nov 2023
dc.description.abstractImaging techniques permit the study of the molecular interactions that underlie health and disease. Each imaging technique collects unique chemical information about the cellular environment. Multimodal imaging, using a single probe that can be detected by multiple imaging modalities, can maximise the information extracted from a single cellular sample by combining the results of different imaging techniques. Of particular interest in biological imaging is the combination of the specificity and sensitivity of optical fluorescence microscopy (OFM) with the quantitative and element-specific nature of X-ray fluorescence microscopy (XFM). Together, these techniques give a greater understanding of how native elements or therapeutics affect the cellular environment. This review focuses on recent studies where both techniques were used in conjunction to study cellular systems, demonstrating the breadth of biological models to which this combination of techniques can be applied and the potential for these techniques to unlock untapped knowledge of disease states.
dc.description.statementofresponsibilityMarcus E. Graziotto, Clinton J. Kidman, Liam D. Adair, Simon A. James, Hugh H. Harris and Elizabeth J. New
dc.identifier.citationChemical Society Reviews, 2023; 52(23):8295-8318
dc.identifier.doi10.1039/d3cs00509g
dc.identifier.issn0306-0012
dc.identifier.issn1460-4744
dc.identifier.orcidHarris, H.H. [0000-0002-3472-8628]
dc.identifier.urihttps://hdl.handle.net/2440/139874
dc.language.isoen
dc.publisherRoyal Society of Chemistry (RSC)
dc.relation.granthttp://purl.org/au-research/grants/arc/CE200100012
dc.relation.granthttp://purl.org/au-research/grants/arc/DP210102148
dc.rights© The Royal Society of Chemistry 2023
dc.source.urihttps://doi.org/10.1039/d3cs00509g
dc.subjectMicroscopy
dc.subjectX-Rays
dc.subjectOptical Imaging
dc.titleTowards multimodal cellular imaging: optical and X-ray fluorescence
dc.typeJournal article
pubs.publication-statusPublished online

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