Randomised controlled trials of behavioural nudges delivered through text messages to increase influenza and COVID-19 vaccines among pregnant women (the EPIC study): study protocol

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dc.contributor.authorAndraweera, P.H.
dc.contributor.authorWang, B.
dc.contributor.authorDanchin, M.
dc.contributor.authorBlyth, C.
dc.contributor.authorVlaev, I.
dc.contributor.authorOng, J.
dc.contributor.authorDodd, J.
dc.contributor.authorCouper, J.
dc.contributor.authorSullivan, T.R.
dc.contributor.authorKarnon, J.
dc.contributor.authorSpurrier, N.
dc.contributor.authorCusack, M.
dc.contributor.authorMordaunt, D.
dc.contributor.authorSimatos, D.
dc.contributor.authorDekker, G.
dc.contributor.authorCarlson, S.
dc.contributor.authorTuckerman, J.
dc.contributor.authorWood, N.
dc.contributor.authorWhop, L.
dc.contributor.authorMarshall, H.S.
dc.date.issued2023
dc.descriptionPublished online: 12 July 2023
dc.description.abstractBACKGROUND: Influenza and COVID-19 infections during pregnancy may have serious adverse consequences for women as well as their infants. However, uptake of influenza and COVID-19 vaccines during pregnancy remains suboptimal. This study aims to assess the effectiveness of a multi-component nudge intervention to improve influenza and COVID-19 vaccine uptake among pregnant women. METHODS: Pregnant women who receive antenatal care at five tertiary hospitals in South Australia, Western Australia and Victoria will be recruited to two separate randomised controlled trials (RCTs). Women will be eligible for the COVID-19 RCT is they have received two or less doses of a COVID-19 vaccine. Women will be eligible for the influenza RCT if they have not received the 2023 seasonal influenza vaccine. Vaccination status at all stages of the trial will be confirmed by the Australian Immunisation Register (AIR). Participants will be randomised (1:1) to standard care or intervention group (n = 1038 for each RCT). The nudge intervention in each RCT will comprise three SMS text message reminders with links to short educational videos from obstetricians, pregnant women and midwives and vaccine safety information. The primary outcome is at least one dose of a COVID-19 or influenza vaccine during pregnancy, as applicable. Logistic regression will compare the proportion vaccinated between groups. The effect of treatment will be described using odds ratio with a 95% CI. DISCUSSION: Behavioural nudges that facilitate individual choices within a complex context have been successfully used in other disciplines to stir preferred behaviour towards better health choices. If our text-based nudges prove to be successful in improving influenza and COVID-19 vaccine uptake among pregnant women, they can easily be implemented at a national level. TRIAL REGISTRATION: ClinicalTrials.gov Identifier NCT05613751. Registered on November 14, 2022.
dc.description.statementofresponsibilityPrabha H. Andraweera, Bing Wang, Margie Danchin, Christopher Blyth, Ivo Vlaev, Jason Ong, Jodie Dodd, Jennifer Couper, Thomas R. Sullivan, Jonathan Karnon, Nicola Spurrier, Michael Cusack, Dylan Mordaunt, Dimi Simatos, Gus Dekker, Samantha Carlson, Jane Tuckerman, Nicholas Wood, Lisa Whop and Helen S. Marshall
dc.identifier.citationTrials, 2023; 24(1):454-1-454-8
dc.identifier.doi10.1186/s13063-023-07485-9
dc.identifier.issn1745-6215
dc.identifier.issn1745-6215
dc.identifier.orcidAndraweera, P.H. [0000-0003-2434-8370]
dc.identifier.orcidWang, B. [0000-0003-2445-2952]
dc.identifier.orcidDodd, J. [0000-0002-6363-4874]
dc.identifier.orcidCouper, J. [0000-0003-4448-8629]
dc.identifier.orcidSullivan, T.R. [0000-0002-6930-5406]
dc.identifier.orcidKarnon, J. [0000-0003-3220-2099]
dc.identifier.orcidMordaunt, D. [0000-0002-9775-0603]
dc.identifier.orcidDekker, G. [0000-0002-7362-6683]
dc.identifier.orcidMarshall, H.S. [0000-0003-2521-5166]
dc.identifier.urihttps://hdl.handle.net/2440/139121
dc.language.isoen
dc.publisherBioMed Central
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/2014684
dc.rights© Crown 2023. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creat ivecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
dc.source.urihttps://doi.org/10.1186/s13063-023-07485-9
dc.subjectCOVID-19
dc.subjectInfluenza
dc.subjectVaccine
dc.subjectPregnancy
dc.subjectRandomised controlled trial
dc.subjectRCT
dc.subject.meshHumans
dc.subject.meshInfluenza Vaccines
dc.subject.meshPregnancy
dc.subject.meshInfant
dc.subject.meshPregnant Women
dc.subject.meshVictoria
dc.subject.meshFemale
dc.subject.meshInfluenza, Human
dc.subject.meshRandomized Controlled Trials as Topic
dc.subject.meshText Messaging
dc.subject.meshCOVID-19
dc.subject.meshCOVID-19 Vaccines
dc.titleRandomised controlled trials of behavioural nudges delivered through text messages to increase influenza and COVID-19 vaccines among pregnant women (the EPIC study): study protocol
dc.typeJournal article
pubs.publication-statusPublished

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