Exercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet

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dc.contributor.authorTan, J.T.M.
dc.contributor.authorPrice, K.J.
dc.contributor.authorFanshaw, S.-R.
dc.contributor.authorBilu, C.
dc.contributor.authorPham, Q.T.
dc.contributor.authorPham, A.
dc.contributor.authorSandeman, L.
dc.contributor.authorNankivell, V.A.
dc.contributor.authorSolly, E.L.
dc.contributor.authorKronfeld-Schor, N.
dc.contributor.authorBursill, C.A.
dc.date.issued2024
dc.description.abstractCircadian disruption causes glucose intolerance, cardiac fibrosis, and adipocyte dysfunction in sand rats (Psammomys obesus). Exercise intervention can improve glucose metabolism, insulin sensitivity, adipose tissue function and protect against inflammation.  We investigated the influence of exercise on male P. obesus exposed to a short photoperiod (5 h light:19 h dark) and high-energy diet. Exercise reduced glucose intolerance. Exercise reduced cardiac expression of inflammatory marker Ccl2 and Bax:Bcl2 apoptosis ratio. Exercise increased heart:body weight ratio and hypertrophy marker Myh7:Myh6, yet reduced Gata4 expression. No phenotypic changes were observed in perivascular fibrosis and myocyte area. Exercise reduced visceral adipose expression of inflammatory transcription factor Rela, adipogenesis marker Ppard and browning marker Ppargc1a, but visceral adipocyte size was unaffected. Conversely, exercise reduced subcutaneous adipocyte size but did not affect any molecular mediators. Exercise increased ZT7 Bmal1 and Per2 in the suprachiasmatic nucleus and subcutaneous Per2. Our study provides new molecular insights and histological assessments on the effect of exercise on cardiac inflammation, adipose tissue dysfunction and circadian gene expression in P. obesus exposed to short photoperiod and high-energy diet. These findings have implications for the protective benefits of exercise for shift workers in order to reduce the risk of diabetes and cardiovascular disease.
dc.description.statementofresponsibilityJoanne T. M. Tan, Kiara J. Price, Sarah-Rose Fanshaw, Carmel Bilu, Quang Tuan Pham, Anthony Pham, Lauren Sandeman, Victoria A. Nankivell, Emma L. Solly, Noga Kronfeld-Schor, and Christina A. Bursill
dc.identifier.citationInternational Journal of Molecular Sciences, 2024; 25(14):7756-1-7756-13
dc.identifier.doi10.3390/ijms25147756
dc.identifier.issn1422-0067
dc.identifier.issn1422-0067
dc.identifier.orcidTan, J.T.M. [0000-0003-1875-4882]
dc.identifier.orcidNankivell, V.A. [0000-0003-3842-9278]
dc.identifier.orcidSolly, E.L. [0000-0001-9992-1181]
dc.identifier.orcidBursill, C.A. [0000-0002-0682-8760] [0000-0003-1087-7781]
dc.identifier.urihttps://hdl.handle.net/2440/143124
dc.language.isoen
dc.publisherMDPI AG
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1184571
dc.rights© 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/).
dc.source.urihttp://dx.doi.org/10.3390/ijms25147756
dc.subjectMyocardium
dc.subjectAdipose Tissue
dc.subjectAnimals
dc.subjectGerbillinae
dc.subjectGlucose Intolerance
dc.subjectInflammation
dc.subjectPhysical Conditioning, Animal
dc.subjectPhotoperiod
dc.subjectMale
dc.subjectDiet, High-Fat
dc.subject.meshMyocardium
dc.subject.meshAdipose Tissue
dc.subject.meshAnimals
dc.subject.meshGerbillinae
dc.subject.meshGlucose Intolerance
dc.subject.meshInflammation
dc.subject.meshPhysical Conditioning, Animal
dc.subject.meshPhotoperiod
dc.subject.meshMale
dc.subject.meshDiet, High-Fat
dc.titleExercise Reduces Glucose Intolerance, Cardiac Inflammation and Adipose Tissue Dysfunction in Psammomys obesus Exposed to Short Photoperiod and High Energy Diet
dc.typeJournal article
pubs.publication-statusPublished online

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