The Knowledge Translation of Early Cerebral Palsy (KiTE CP) study: Implementing Screening among a High-risk Prospective Cohort of Australian Infants

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dc.contributor.authorKwong, A.K.L.
dc.contributor.authorEeles, A.L.
dc.contributor.authorAnderson, P.J.
dc.contributor.authorBadawi, N.
dc.contributor.authorBoyd, R.N.
dc.contributor.authorCameron, K.L.
dc.contributor.authorCheong, J.L.Y.
dc.contributor.authorColditz, P.
dc.contributor.authorKoorts, P.
dc.contributor.authorCrowle, C.
dc.contributor.authorDale, R.C.
dc.contributor.authorDoyle, L.W.
dc.contributor.authorFahey, M.
dc.contributor.authorGeorge, J.
dc.contributor.authorHunt, R.W.
dc.contributor.authorMcNamara, L.
dc.contributor.authorMorgan, C.
dc.contributor.authorNovak, I.
dc.contributor.authorOlsen, J.E.
dc.contributor.authorReid, N.
dc.contributor.authoret al.
dc.date.issued2024
dc.descriptionThis article was accepted for publication on 19 April 2024.
dc.description.abstractObjective To describe the implementation of the international guidelines for the early diagnosis of cerebral palsy (CP) and engagement in the screening process in an Australian cohort of infants with neonatal risk factors for CP. Study design Prospective cohort study of infants with neonatal risk factors recruited at <6 months corrected age from11 sites in the states of Victoria, New South Wales, and Queensland, Australia. First, we implemented a multimodal knowledge translation strategy including barrier identification, technology integration, and special interest groups. Screening was implemented as follows: infants with clinical indications for neuroimaging underwent magnetic resonance imaging and/or cranial ultrasound. The Prechtl General Movements Assessment (GMA) was recorded clinically or using an app (Baby Moves). Infants with absent or abnormal fidgety movements on GMA videos were offered further assessment using the Hammersmith Infant Neurological Examination (HINE). Infants with atypical findings on 2/3 assessments met criteria for high risk of CP. Results Of the 597 infants (56% male) recruited, 95% (n = 565) received neuroimaging, 90% (n = 537) had scorable GMA videos (2% unscorable/ 8% no video), and 25% (n = 149) HINE. Overall, 19% of the cohort (n = 114/597) met criteria for high risk of CP, 57% (340/597) had at least 2 normal assessments (of neuroimaging, GMA or HINE), and 24% (n = 143/597) had insufficient assessments. Conclusions Early CP screening was implemented across participating sites using a multimodal knowledge translation strategy. Although the COVID-19 pandemic affected recruitment rates, there was high engagement in the screening process. Reasons for engagement in early screening from parents and clinicians warrant further contextualization and investigation.
dc.description.statementofresponsibilityAmanda K. L. Kwong, Abbey L. Eeles, Peter J. Anderson, Nadia Badawi, Roslyn N. Boyd, Kate L. Cameron, Jeanie L. Y. Cheong, Paul Colditz, Pieter Koorts, Cathryn Crowle, Russell C. Dale, Lex W. Doyle, Michael Fahey, Joanne George, Rod W. Hunt, Lynda McNamara, Catherine Morgan, Iona Novak, Joy E. Olsen, Nadia Reid, Ingrid Rieger, Koa Whittingham, and Alicia J. Spittle
dc.identifier.citationJournal of Pediatrics, 2024; 268:113949-1-113949-7
dc.identifier.doi10.1016/j.jpeds.2024.113949
dc.identifier.issn0022-3476
dc.identifier.issn1097-6833
dc.identifier.orcidAnderson, P.J. [0000-0002-3730-4652]
dc.identifier.urihttps://hdl.handle.net/2440/142526
dc.language.isoen
dc.publisherElsevier
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1152800
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1078851
dc.relation.granthttp://purl.org/au-research/grants/nhmrc/1105038
dc.rightsCrown Copyright © 2024 Published by Elsevier Inc. This is an open access article under the CC BY license (http:// creativecommons.org/licenses/by/4.0/).
dc.source.urihttp://dx.doi.org/10.1016/j.jpeds.2024.113949
dc.subjectcerebral palsy
dc.subjectearly detection
dc.subjectgeneral movements assessment
dc.subjecthigh-risk infant
dc.subject.meshHumans
dc.subject.meshCerebral Palsy
dc.subject.meshMagnetic Resonance Imaging
dc.subject.meshNeurologic Examination
dc.subject.meshNeonatal Screening
dc.subject.meshEarly Diagnosis
dc.subject.meshRisk Factors
dc.subject.meshCohort Studies
dc.subject.meshProspective Studies
dc.subject.meshInfant
dc.subject.meshInfant, Newborn
dc.subject.meshAustralia
dc.subject.meshFemale
dc.subject.meshMale
dc.subject.meshNeuroimaging
dc.subject.meshCOVID-19
dc.subject.meshTranslational Research, Biomedical
dc.titleThe Knowledge Translation of Early Cerebral Palsy (KiTE CP) study: Implementing Screening among a High-risk Prospective Cohort of Australian Infants
dc.typeJournal article
pubs.publication-statusPublished

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