Current studentsExisting staffContact us
 

Unchanged cardiovascular and respiratory outcomes in healthy C57Bl/6 mice after in utero exposure to ionizing radiation.

Simple item page
dc.contributor.authorMcevoy, J.
dc.contributor.authorJones, D.E.
dc.contributor.authorStoa, L.
dc.contributor.authorDixon, D.
dc.contributor.authorTai, T.C.
dc.contributor.authorHooker, A.
dc.contributor.authorBoreham, D.R.
dc.contributor.authorWilson, J.Y.
dc.date.issued2021
dc.description.abstractBackground: Advancements in medical technologies that utilize ionizing radiation have led to improved diagnosis and patient outcomes, however, the effect of ionizing radiation on the patient is still debated. In the case of pregnancy, the potential effects are not only to the mother but also to the fetus. The aim of this study was to determine if exposure from ionizing radiation during pregnancy alters the development of the cardiovascular and respiratory system of the offspring. Materials and methods: Pregnant C57Bl/6 mice were whole-body irradiated at gestational day 15 with a ¹³⁷Cs gamma radiation emitting source at 0 mGy (sham), 50 mGy, 300 mGy, or 1000 mGy. Post weaning weight and blood pressure measurements were taken weekly for both male and female pups until euthanasia at 16–17 weeks postnatal age. Immediately following, the trachea was cannulated, and the lungs and heart excised. The lung was then examined to assess respiratory physiological outcomes. Results and conclusions: In utero exposures to 1000 mGy caused significant growth reduction compared to sham irradiated, which remained persistent for both male and female pups. Growth restriction was not observed for lower exposures. There was no significant change in any cardiovascular or respiratory outcomes measured. Overall, intrauterine exposures to ionizing radiation does not appear to significantly alter the development of the cardiovascular and respiratory system in C57Bl/6 pups up to 17weeks postnatal age.
dc.description.statementofresponsibilityJames H. McEvoy-May, Devon E. Jones, Lisa Stoa, Dani-Louise Dixon, T. C Tai, Antony M. Hooker, Douglas R. Boreham, Joanna Y. Wilson
dc.identifier.citationInternational Journal of Radiation Biology, 2021; 97(2):131-138
dc.identifier.doi10.1080/09553002.2021.1855372
dc.identifier.issn0955-3002
dc.identifier.issn1362-3095
dc.identifier.orcidDixon, D. [0000-0001-6459-1856]
dc.identifier.orcidHooker, A. [0000-0003-2324-4748]
dc.identifier.urihttps://hdl.handle.net/2440/146531
dc.language.isoen
dc.publisherTaylor and Francis Group
dc.rights© 2020 Taylor & Francis Group LLC.
dc.source.urihttps://doi.org/10.1080/09553002.2021.1855372
dc.subjectAnimal model organisms; cardiovascular system; deterministic effects of radiation; fetus; respiratory system
dc.subject.meshRespiratory System
dc.subject.meshCardiovascular System
dc.subject.meshFetus
dc.subject.meshAnimals
dc.subject.meshMice, Inbred C57BL
dc.subject.meshMice
dc.subject.meshPrenatal Exposure Delayed Effects
dc.subject.meshMaternal Exposure
dc.subject.meshFetal Development
dc.subject.meshPregnancy
dc.subject.meshGamma Rays
dc.subject.meshFemale
dc.subject.meshMale
dc.titleUnchanged cardiovascular and respiratory outcomes in healthy C57Bl/6 mice after in utero exposure to ionizing radiation.
dc.typeJournal article
pubs.publication-statusPublished

Files

Collections

Research Outputs