IgG4-related orbital disease: a meta-analysis and review
Date
2012
Authors
Andrew, N.
Kearney, D.
Selva-Nayagam, D.
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Journal article
Citation
Acta Ophthalmologica, 2012; online(8):1-7
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Nicholas Andrew, Daniel Kearney and Dinesh Selva
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Abstract
IgG4-related orbital disease (IgG4-ROD) is a recently described condition that may account for a significant proportion of idiopathic lymphoplasmacytic or sclerotic orbital lesions. This study is the first meta-analysis of published cases and reveals several differences between IgG4-related disease affecting the orbit and that affecting the pancreas. IgG4-ROD affects a slightly younger group of patients, affects men and women approximately equally, is commonly associated with salivary gland lesions, is associated with a relatively higher serum IgG4 and may confer an increased risk of non-Hodgkin Lymphoma. Its pathogenesis may involve an immune response to antigen exposure in the upper aerodigestive tract.
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© 2012 The Authors.